Evidence map›Paper›PMID 31332763›Full record

ArticleMolecular neurobiology2020

Avenanthramide-C Restores Impaired Plasticity and Cognition in Alzheimer's Disease Model Mice.

Vijay Sankar Ramasamy, Manikandan Samidurai, Hyung Joon Park, Ming Wang, Ra Young Park, Seon Young Yu, Hee Kyung Kang, Semi Hong, Won-Seok Choi, Yu Young Lee and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

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  15. A PAM of the αCurrent research in pharmacology and drug discovery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Vijay Sankar RamasamyNeuroMedical Convergence Laboratory, Biomedical Research Institute, Chonnam National University Hospital, Jebong-ro, Gwangju, 501-757, Republic of Korea.ORCID http://orcid.org/0000-0002-8791-079X
Manikandan SamiduraiNeuroMedical Convergence Laboratory, Biomedical Research Institute, Chonnam National University Hospital, Jebong-ro, Gwangju, 501-757, Republic of Korea.
Hyung Joon ParkSchool of Biological Sciences and Technology, College of Natural Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea.
Ming WangNeuroMedical Convergence Laboratory, Biomedical Research Institute, Chonnam National University Hospital, Jebong-ro, Gwangju, 501-757, Republic of Korea.
Ra Young ParkBio-Medical treatment technology development projects, Institute for Biomedical Science, Chonnam National University Hwasun Hospital, Gwangju, Republic of Korea.
Seon Young YuForensic Medicine Division, National Forensic Service Daegu Institute, Daegu, 39872, Republic of Korea.
Hee Kyung KangNeuroMedical Convergence Laboratory, Biomedical Research Institute, Chonnam National University Hospital, Jebong-ro, Gwangju, 501-757, Republic of Korea.
Semi HongSchool of Biological Sciences and Technology, College of Natural Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea.
Won-Seok ChoiSchool of Biological Sciences and Technology, College of Natural Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea. choiw@chonnam.ac.kr.
Yu Young LeeDepartment of Central Area, National Institute of Crop Science, Rural Development Administration, Suwon, 16429, Republic of Korea. leeyy260@korea.kr.
Hyung-Seok KimDepartment of Forensic Medicine, Chonnam National University Medical School, Gwangju, South Korea. veritas@chonnam.ac.kr.
Jihoon JoNeuroMedical Convergence Laboratory, Biomedical Research Institute, Chonnam National University Hospital, Jebong-ro, Gwangju, 501-757, Republic of Korea. Jihoon.Jo@chonnam.ac.kr.
Chonnam National University · KRChonnam National University Hwasun Hospital · KRNational Forensic Institute · KRRural Development Administration · KR

Funding

Cooperative Research Program for Agriculture Science & Technology Development PJ010508042014, PJ01255102 and PJ01255104National Research Foundation of Korea 2016R1D1A3B03931710National Research Foundation of Korea NRF-2014M3C1A3053029National Research Foundation of Korea NRF-2016R1A2B4008316
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline and dementia with no effective treatment. Here, we investigated a novel compound from oats named avenanthramide-C (Avn-C), on AD-related memory impairment and behavioral deficits in transgenic mouse models. Acute hippocampal slices of wild-type or AD transgenic mice were treated with Avn-C in the presence or absence of oligomeric Aβ

Indexed as

Adenylate KinaseAdministration, OralAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainCognitionDisease Models, AnimalEnzyme ActivationInflammationLong-Term PotentiationMice, Inbred C57BLMice, TransgenicModels, BiologicalNeuronal Plasticityortho-AminobenzoatesAdenylate KinaseAmyloid beta-Peptidesavenanthramide-2Cortho-AminobenzoatesReceptors, Adrenergic, alpha-1Alzheimer’s diseaseAmyloid-βAvn-CLTPMemoryMouse modelOats

Identifiers

PMID31332763
OpenAlexW2963294137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.