ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2020
Defining microbial biomarkers for risk of preterm labor.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis.Scientific reports · 2022Pooled it
- The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- An in silico framework for the rational design of vaginal probiotic therapy.PLoS computational biology · 2025Article
- Vaginal Microbiome and Pregnancy Complications: A Review.Journal of clinical medicine · 2024Review
- The vaginal microbial signatures of preterm birth woman.BMC pregnancy and childbirth · 2024Article
- Profiling of vaginalMicrobial genomics · 2023Article
- The Vaginal Microbiota of Pregnant Women Varies with Gestational Age, Maternal Age, and Parity.Microbiology spectrum · 2023Article
- Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth.Scientific reports · 2022Article
- Daytime Napping and Nighttime Sleep During Pregnancy and Preterm Birth in Iran.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2021Article
- Relationship Between Vaginal Microbiome and Preterm Birth During Pregnancy: In Different Ethnic Populations.Women's health reports (New Rochelle, N.Y.)Article
- Observational
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Preterm birth remains the main contributor to early childhood mortality. The vaginal environment, including microbiota composition, might contribute to the risk of preterm delivery. Alterations in the vaginal microbial community structure might represent a risk factor for preterm birth. Here, we aimed to (a) investigate the association between preterm birth and the vaginal microbial community and (b) identify microbial biomarkers for risk of preterm birth. Microbial DNA was isolated from vaginal swabs in a cohort of 69 women enrolled at hospital admission for their delivery. Microbiota was analyzed by high-throughput 16S rRNA sequencing. While no differences in microbial diversity measures appeared associated with the spontaneous preterm and full-term outcomes, the microbial composition was distinct for these groups. Differential abundance analysis showed Lactobacillus species to be associated with full-term birth whereas an unknown Prevotella species was more abundant in the spontaneous preterm group. Although we studied a very miscegenated population from Brazil, our findings were similar to evidence pointed by other studies in different countries. The role of Lactobacillus species as a protector in the vaginal microbiome is demonstrated to be also a protector of spontaneous preterm outcome whereas the presence of pathogenic species, such as Prevotella spp., is endorsed as a factor of risk for spontaneous preterm delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.