Evidence map›Paper›PMID 31332480›Full record

ArticlePediatric radiology2019

Whole-body magnetic resonance imaging in paediatric Hodgkin lymphoma - evaluation of quantitative magnetic resonance metrics for nodal staging.

Arash Latifoltojar, Paul D Humphries, Leon J Menezes, Athar Haroon, Stephen Daw, Ananth Shankar, Shonit Punwani

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  3. PET/MRI Improves Management of Children with Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Arash LatifoltojarCentre for Medical Imaging, University College London, 2nd floor, Charles Bell House, 43-45 Foley St., London, W1W 7TS, UK.
Paul D HumphriesCentre for Medical Imaging, University College London, 2nd floor, Charles Bell House, 43-45 Foley St., London, W1W 7TS, UK.
Leon J MenezesInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Athar HaroonInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Stephen DawDepartment of Paediatric Haemato-oncology, University College London Hospitals, London, UK.
Ananth ShankarDepartment of Paediatric Haemato-oncology, University College London Hospitals, London, UK.
Shonit PunwaniCentre for Medical Imaging, University College London, 2nd floor, Charles Bell House, 43-45 Foley St., London, W1W 7TS, UK. shonit.punwani@gmail.com.
Royal London Hospital · GBUniversity College London · GB

Funding

Cancer Research UK 27066
6 · The paper itself

Abstract

backgroundWhole-body MRI is used for staging paediatric Hodgkin lymphoma, commonly using size thresholds, which fail to detect disease in normal-size lymph nodes.

objectiveTo investigate quantitative whole-body MRI metrics for nodal characterisation. MATERIALS AND

methodsThirty-seven children with Hodgkin lymphoma underwent 1.5-tesla (T) whole-body MRI using short tau inversion recovery (STIR) half-Fourier-acquisition single-shot turbo-spin-echo and diffusion-weighted imaging (DWI).

resultsROC/AUC values for reader 1/reader 2 were 0.80/0.80 and 0.81/0.81 for short-axis-diameter measured using DWI and STIR half-Fourier-acquisition single-shot turbo spin echo, respectively; 0.67/0.72 for normalised T2 signal intensity and 0.74/0.67 for ADC. Sensitivity and specificity for a short-axis diameter ≥10 mm were 84.2% and 66.7% for Reader 1 and 82.9% and 68.9% for Reader 2. Applying a short-axis-diameter ≥10-mm threshold followed by ADC cut-offs to normal-size 5- to 9-mm nodes resulted in sensitivity and specificity for Reader 1 of 88.8% and 60%, 92.1% and 56.7%, and 100% and 16.7%; and for Reader 2, 86.1% and 67.2%, 95.3% and 65.6%, and 100% and 19.7%; and ADC thresholds of <0.77, <1.15, and <1.79×10

conclusionNodal size measurement provides the best single classifier for nodal disease status in paediatric Hodgkin lymphoma. Combined short-axis diameter and ADC thresholds marginally improve sensitivity and drop specificity compared with size classification alone.

Indexed as

Hodgkin DiseaseLymph NodesMagnetic Resonance ImagingWhole Body ImagingAdolescentChildFemaleHumansMaleNeoplasm StagingSensitivity and SpecificityAdolescentsChildrenDiffusion-weighted imagingHodgkin lymphomaMagnetic resonance imagingStaging

Identifiers

PMID31332480
PMCPMC6710223
OpenAlexW2963001246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.