Evidence map›Paper›PMID 31332447›Full record

ArticleThe Journal of infectious diseases2019

Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children With Nontuberculous Mycobacterial Infection.

Tiffany A Claeys, Oscar Rosas Mejia, Samuel Marshall, Jason A Jarzembowski, Don Hayes, Natalie M Hull, Namal P M Liyanage, Robert H Chun, Cecille G Sulman, Anna R Huppler and 1 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Exacerbation ofVirulence · 2021
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Tiffany A ClaeysDepartment of Microbial Infection & Immunity, The Ohio State University, Columbus.
Oscar Rosas MejiaDepartment of Microbial Infection & Immunity, The Ohio State University, Columbus.
Samuel MarshallDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee.
Jason A JarzembowskiDepartment of Pathology, Medical College of Wisconsin, Medical College of Wisconsin, Milwaukee.
Don HayesDepartment of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus.
Natalie M HullDepartment of Civil, Environmental, and Architectural Engineering, The Ohio State University, Columbus.
Namal P M LiyanageDepartment of Microbial Infection & Immunity, The Ohio State University, Columbus.
Robert H ChunDivision of Pediatric Otolaryngology, Department of Surgery, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee.
Cecille G SulmanDivision of Pediatric Otolaryngology, Department of Surgery, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee.
Anna R HupplerDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee.
Richard T RobinsonDepartment of Microbial Infection & Immunity, The Ohio State University, Columbus.
The Ohio State University · USChildren's Hospital of Wisconsin · USMedical College of Wisconsin · USNationwide Children's Hospital · US

Funding

Regulation of human IL12/IL23 responsiveness by IL12RB1R01AI121212 · NIAID · OHIO STATE UNIVERSITY · PI ROBINSON, RICHARD · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI121212
6 · The paper itself

Abstract

Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide. Using blood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from community controls, we evaluated helper T (TH) cells in functional assays of TH1/TH17 differentiation and measured the concentration of their associated cytokines at the site of infection. Circulating TH cells from infected children were attenuated in their TH1/TH17 differentiation capacity and expressed less interferon γ and interleukin 17 after polyclonal stimulation. Similar differences were observed at the site of infection, where most cytokine concentrations were unchanged relative to controls. Our data are consistent with a model wherein TH1/TH17 differentiation is attenuated in NTM-infected children.

Indexed as

Cell DifferentiationAdolescentBloodChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornInterferon-gammaInterleukin-17Lymph NodesMaleMycobacterium InfectionsNontuberculous MycobacteriaIL17A protein, humanInterferon-gammaInterleukin-17childrenimmunemycobacteriaNontuberculousNTMpediatricTH1 and TH17 cells

Identifiers

PMID31332447
PMCPMC7325325
OpenAlexW2964281943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.