ArticleScientific reports2019
Ex Vivo and In Vivo Biocompatibility Assessment (Blood and Tissue) of Three-Dimensional Bacterial Nanocellulose Biomaterials for Soft Tissue Implants.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Bacterial Nanocellulose Hydrogels as a Next-Generation Biomaterial for Cardiac and Vascular Tissue Engineering: Structural, Biological, and Translational Perspectives.Gels (Basel, Switzerland) · 2026Review
- A modified bacterial nanocellulose-based advanced therapy product accelerates third-degree burn healing in murine models.NPJ Regenerative medicine · 2026Article
- Bacterial cellulose-enhanced MTA versus conventional MTA for indirect pulp capping in primary teeth: a randomized controlled clinical trial.The Saudi dental journal · 2026Article
- Ultraminiaturized neural implanted constructs display minimal immunologic response.Materials today. Bio · 2025Article
- Enhanced Cell Proliferation and Maturation Using Carboxylated Bacterial Nanocellulose Scaffolds for 3D Cell Culture.ACS applied materials & interfaces · 2025Article
- Standardizing decellularization protocols for optimized uterine tissue bioengineering.Regenerative therapy · 2025Review
- Review
- Mucoadhesive capsules based on bacterial nanocellulose and chitosan as delivery system of turmeric extract.Heliyon · 2023Article
- Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications.ACS materials Au · 2023Review
- Controlled Drug Release from Nanoengineered Polysaccharides.Pharmaceutics · 2023Review
- Material matters: exploring the interplay between natural biomaterials and host immune system.Frontiers in immunology · 2023Review
- Development of Genistein Drug Delivery Systems Based on Bacterial Nanocellulose for Potential Colorectal Cancer Chemoprevention: Effect of Nanocellulose Surface Modification on Genistein Adsorption.Molecules (Basel, Switzerland) · 2022Article
- Thermally responsive hydrogel for atrial fibrillation related stroke prevention.Materials today. Bio · 2022Article
- A novel antimicrobial-containing nanocellulose scaffold for regenerative endodontics.Restorative dentistry & endodontics · 2021Article
- Fabrication and characterization of 3D printable nanocellulose-based hydrogels for tissue engineering.RSC advances · 2021Article
- Thermoplastic Polymers with Nanosilver Addition-Microstructural, Surface and Mechanical Evaluation during a 36-Month Deionized Water Incubation Period.Materials (Basel, Switzerland) · 2021Article
- Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases.Frontiers in bioengineering and biotechnology · 2021Review
- Nanocellulose-Based Scaffolds for Chondrogenic Differentiation and Expansion.Frontiers in bioengineering and biotechnology · 2021Review
- Bacterial Cellulose Properties Fulfilling Requirements for a Biomaterial of Choice in Reconstructive Surgery and Wound Healing.Frontiers in bioengineering and biotechnology · 2021Review
- Interactions at engineered graft-tissue interfaces: A review.APL bioengineering · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial nanocellulose (BNC) is a promising biomedical material. However, the haemocompatibility (haemolysis and thrombogenicity) and acute and sub-chronic immune responses to three-dimensional (3D) BNC biomaterials have not been evaluated. Accordingly, this manuscript focused on the effect of 3D microporosity on BNC haemocompatibility and a comparison with 2D BNC architecture, followed by the evaluation of the immune response to 3D BNC. Blood ex vivo studies indicated that compared with other 2D and 3D BNC architectures, never-dried 2D BNC presented antihemolytic and antithrombogenic effects. Nevertheless, in vivo studies indicated that 3D BNC did not interfere with wound haemostasis and elicited a mild acute inflammatory response, not a foreign body or chronic inflammatory response. Moreover, compared with the polyethylene controls, the implant design with micropores ca. 60 µm in diameter showed a high level of collagen, neovascularization and low fibrosis. Cell/tissue infiltration increased to 91% after 12 weeks and was characterized by fibroblastic, capillary and extracellular matrix infiltration. Accordingly, 3D BNC biomaterials can be considered a potential implantable biomaterial for soft tissue augmentation or replacement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.