Evidence map›Paper›PMID 31332195›Full record

ArticleScientific data2019

X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline.

Augusto Anguita-Ruiz, Julio Plaza-Diaz, Francisco Javier Ruiz-Ojeda, Azahara I Rupérez, Rosaura Leis, Gloria Bueno, Mercedes Gil-Campos, Rocío Vázquez-Cobela, Ramón Cañete, Luis A Moreno and 2 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Augusto Anguita-RuizDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, 18011, Spain. augustoanguitaruiz@gmail.com.ORCID http://orcid.org/0000-0001-6888-1041
Julio Plaza-DiazDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, 18011, Spain.
Francisco Javier Ruiz-OjedaDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, 18011, Spain.
Azahara I RupérezDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, 18011, Spain.ORCID http://orcid.org/0000-0002-3850-8235
Rosaura LeisCIBEROBN, (Physiopathology of Obesity and Nutrition CB12/03/30038), Institute of Health Carlos III (ISCIII), Madrid, 28029, Spain.
Gloria BuenoCIBEROBN, (Physiopathology of Obesity and Nutrition CB12/03/30038), Institute of Health Carlos III (ISCIII), Madrid, 28029, Spain.
Mercedes Gil-CamposCIBEROBN, (Physiopathology of Obesity and Nutrition CB12/03/30038), Institute of Health Carlos III (ISCIII), Madrid, 28029, Spain.
Rocío Vázquez-CobelaCIBEROBN, (Physiopathology of Obesity and Nutrition CB12/03/30038), Institute of Health Carlos III (ISCIII), Madrid, 28029, Spain.
Ramón CañeteCIBEROBN, (Physiopathology of Obesity and Nutrition CB12/03/30038), Institute of Health Carlos III (ISCIII), Madrid, 28029, Spain.
Luis A MorenoGrowth, Exercise, Nutrition and Development (GENUD) Research Group, Universidad de Zaragoza, Zaragoza, Spain.
Ángel GilDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, 18011, Spain.ORCID http://orcid.org/0000-0001-7663-0939
Concepción María AguileraDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, 18011, Spain.ORCID http://orcid.org/0000-0002-1451-4788

Funding

Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) IFI17/00048Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI051968Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI1102042Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI1600871
6 · The paper itself

Abstract

X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics have been developed, there is also a lack of readily available implementations for routine analysis. Here, we aimed: (1) to make public and describe a dataset incorporating phenotype and X chromosome genotype data from a cohort of 915 normal-weight, overweight and obese children, and (2) to deeply describe a whole implementation of the special X chromosome analytic process in genetics. Datasets and pipelines like this are crucial to get familiar with the steps in which X chromosome requires special attention and may raise awareness of the importance of this genomic region.

Indexed as

ChildChromosomes, Human, XFemaleGene FrequencyGenotypeHumansMaleOverweightPediatric ObesityPhenotypeSpain

Identifiers

PMID31332195
PMCPMC6646348

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.