ArticleNature communications2019
Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Heterokairic Genes and the Eco-Evo-Devo of Timing.Evolution & development · 2026Review
- Adaptation to Hot and Humid Climates in the Silkworm: Energy Reallocation and Cuticle Transpiration.Insects · 2025Article
- Assembly of a functional neuronal circuit in embryos of an ancestral metazoan is influenced by temperature and the microbiome.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A PAK family kinase and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The impact of food availability on tumorigenesis is evolutionarily conserved.Scientific reports · 2023Article
- Article
- FOXOs: masters of the equilibrium.The FEBS journal · 2022Review
- Article
- Article
- Function and Evolution of Nuclear Receptors in Environmental-Dependent Postembryonic Development.Frontiers in cell and developmental biology · 2021Review
- Animal development in the microbial world: The power of experimental model systems.Current topics in developmental biology · 2021Review
- Bacteria- and temperature-regulated peptides modulate β-catenin signaling inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Prototypical pacemaker neurons interact with the resident microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra.PLoS pathogens · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How multicellular organisms assess and control their size is a fundamental question in biology, yet the molecular and genetic mechanisms that control organ or organism size remain largely unsolved. The freshwater polyp Hydra demonstrates a high capacity to adapt its body size to different temperatures. Here we identify the molecular mechanisms controlling this phenotypic plasticity and show that temperature-induced cell number changes are controlled by Wnt- and TGF-β signaling. Further we show that insulin-like peptide receptor (INSR) and forkhead box protein O (FoxO) are important genetic drivers of size determination controlling the same developmental regulators. Thus, environmental and genetic factors directly affect developmental mechanisms in which cell number is the strongest determinant of body size. These findings identify the basic mechanisms as to how size is regulated on an organismic level and how phenotypic plasticity is integrated into conserved developmental pathways in an evolutionary informative model organism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.