Evidence map›Paper›PMID 31332169›Full record

ArticleNature communications2019

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response.

Krist Helen Antunes, José Luís Fachi, Rosemeire de Paula, Emanuelle Fraga da Silva, Laís Passariello Pral, Adara Áurea Dos Santos, Greicy Brisa Malaquias Dias, José Eduardo Vargas, Renato Puga, Fabiana Quoos Mayer and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 245 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
245citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

245 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Nutrients · 2023
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  15. The gut-lung axis in early life: microbiome-associated mechanisms and clinical relevance.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
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185 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Krist Helen AntunesLaboratory of Clinical and Experimental Immunology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90610-000, RS, Brazil.ORCID http://orcid.org/0000-0002-1525-6581
José Luís FachiLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, 13083007, São Paulo, Brazil.
Rosemeire de PaulaLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, 13083007, São Paulo, Brazil.
Emanuelle Fraga da SilvaLaboratory of Clinical and Experimental Immunology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90610-000, RS, Brazil.
Laís Passariello PralLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, 13083007, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-3008-0465
Adara Áurea Dos SantosLaboratory of Imunobiology, Departament of Microbiology, Immunology and Parasitology, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Santa Catarina, 88040900, Brazil.
Greicy Brisa Malaquias DiasLaboratory of Imunobiology, Departament of Microbiology, Immunology and Parasitology, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Santa Catarina, 88040900, Brazil.
José Eduardo VargasBiological Science Institute (ICB), Passo Fundo University, Passo Fundo, 99052900, State of Rio Grande do Sul, Brazil.
Renato PugaClinical Research Center, Hospital Israelita Albert Einstein HIAE, São Paulo, 05652900, Brazil.ORCID http://orcid.org/0000-0002-6366-0765
Fabiana Quoos MayerMolecular Biology Laboratory, Veterinary Research Institute Desidério Finamor, Agricultural Diagnosis and Research Department, Secretariat of Agriculture, Livestock and Irrigation, Eldorado do Sul, 92990000, RS, Brazil.
Fábio MaitoLaboratory of Pathology, Healthy Science School, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90610-000, RS, Brazil.
Carlos R Zárate-BladésLaboratory of Iimmunoregulation, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, UFSC, Florianopolis, 8804900, SC, Brazil.
Nadim J AjamiAlkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-3808-8576
Marcella Ramos Sant'AnaLaboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, 13484350, São Paulo, Brazil.
Thamiris CandrevaLaboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas, Limeira, 13484350, São Paulo, Brazil.
Hosana Gomes RodriguesLaboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas, Limeira, 13484350, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-6122-0379
Marcio SchmieleInstitute of Science and Technology, Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Teófilo Otoni, 39803371, MG, Brazil.
Maria Teresa Pedrosa Silva ClericiDepartment of Food Technology, School of Food Engineering, University of Campinas (UNICAMP) - Cidade Universitária Zeferino Vaz, Monteiro Lobato, 80, Campinas, 13083970, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-8445-336X
José Luiz Proença-ModenaEmerging viruses study Laboratory, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, 13083970, Brazil.
Angélica Thomas VieiraDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, 31270901, MG, Brazil.ORCID http://orcid.org/0000-0002-4556-7671
Charles R MackayBiodiscovery Research Institute, Monash University, Clayton, 3800, Australia.ORCID http://orcid.org/0000-0002-6338-7340
Daniel MansurLaboratory of Imunobiology, Departament of Microbiology, Immunology and Parasitology, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Santa Catarina, 88040900, Brazil.ORCID http://orcid.org/0000-0001-6773-9334
Mauricio T CaballeroFundación INFANT, Buenos Aires, 1406, Argentina.ORCID http://orcid.org/0000-0002-4218-5942
Jacqui MarzecNational Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle, Durham, 27709, NC, USA.
Jianying LiNational Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle, Durham, 27709, NC, USA.
Xuting WangNational Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle, Durham, 27709, NC, USA.
Douglas BellNational Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle, Durham, 27709, NC, USA.
Fernando P PolackFundación INFANT, Buenos Aires, 1406, Argentina.
Steven R KleebergerNational Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle, Durham, 27709, NC, USA.
Renato T SteinInfant Center, School of Medicine, Department of Pediatrics, São Lucas Hospital PUCRS, Porto Alegre, 90610-000, RS, Brazil.
Marco Aurélio Ramirez VinoloLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, 13083007, São Paulo, Brazil. mvinolo@unicamp.br.
Ana Paula Duarte de SouzaLaboratory of Clinical and Experimental Immunology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90610-000, RS, Brazil. ana.duarte@pucrs.br.ORCID http://orcid.org/0000-0002-6021-5068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acetate mediated interferon-β (IFN-β) response by increasing expression of interferon-stimulated genes in the lung. These effects were associated with reduction of viral load and pulmonary inflammation in RSV-infected mice. Type 1 IFN signaling via the IFN-1 receptor (IFNAR) was essential for acetate antiviral activity in pulmonary epithelial cell lines and for the acetate protective effect in RSV-infected mice. Activation of Gpr43 in pulmonary epithelial cells reduced virus-induced cytotoxicity and promoted antiviral effects through IFN-β response. The effect of acetate on RSV infection was abolished in Gpr43

Indexed as

MicrobiotaA549 CellsAcetatesAnimalsCell LineChlorocebus aethiopsHumansInterferon Type ILungMice, Inbred C57BLMice, KnockoutPolymorphism, Single NucleotideProtective AgentsReceptor, Interferon alpha-betaReceptors, G-Protein-CoupledRespiratory Syncytial Virus InfectionsAcetatesFfar2 protein, mouseIfnar1 protein, mouseInterferon Type IProtective AgentsReceptor, Interferon alpha-betaReceptors, G-Protein-Coupled

Identifiers

PMID31332169
PMCPMC6646332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.