Evidence map›Paper›PMID 31332058›Full record

ArticleAntimicrobial agents and chemotherapy2019

Impact of Triazole Therapeutic Drug Monitoring Availability and Timing.

Erin K McCreary, Meg Bayless, Ahn P Van, Alexander J Lepak, Donald A Wiebe, Lucas T Schulz, David R Andes

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. ISCCM Position Statement on the Management of Invasive Fungal Infections in the Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erin K McCrearyDepartment of Pharmacy, University of Wisconsin Health, Madison, Wisconsin, USA.
Meg BaylessDepartment of Medicine, Division of Infectious Diseases, University of Wisconsin, Madison, Wisconsin, USA.
Ahn P VanDepartment of Pharmacy, University of Wisconsin Health, Madison, Wisconsin, USA.
Alexander J LepakDepartment of Medicine, Division of Infectious Diseases, University of Wisconsin, Madison, Wisconsin, USA.
Donald A WiebeDepartment of Pathology, University of Wisconsin, Madison, Wisconsin, USA.
Lucas T SchulzDepartment of Pharmacy, University of Wisconsin Health, Madison, Wisconsin, USA.
David R AndesDepartment of Medicine, Division of Infectious Diseases, University of Wisconsin, Madison, Wisconsin, USA dra@medicine.wisc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic drug monitoring (TDM) is an established strategy to optimize antifungal therapy with certain triazoles. While established relationships exist between concentration and safety or efficacy, the impact of TDM timing on outcomes is unknown. We report clinical outcomes, including antifungal exposure and mortality, in patients receiving institutional versus reference laboratory TDM. The availability of in-house triazole assays reduced the time to drug concentration result (12 versus 68 h;

Indexed as

AdolescentAdultAgedAged, 80 and overAntifungal AgentsDrug MonitoringFemaleHumansInvasive Fungal InfectionsItraconazoleMaleMiddle AgedRetrospective StudiesTriazolesVoriconazoleYoung AdultAntifungal AgentsItraconazoleposaconazoleTriazolesVoriconazoleantifungalpharmacodynamicstherapeutic drug monitoringtimingtriazole

Identifiers

PMID31332058
PMCPMC6761504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.