Evidence map›Paper›PMID 31332038›Full record

ArticleDevelopment (Cambridge, England)2019

Rorβ regulates selective axon-target innervation in the mammalian midbrain.

Haewon Byun, Hae-Lim Lee, Hong Liu, Douglas Forrest, Andrii Rudenko, In-Jung Kim

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Haewon ByunDepartment of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06511, USA.
Hae-Lim LeeDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06511, USA.
Hong LiuLaboratory of Endocrinology and Receptor Biology, National Institutes of Health, NIDDK, Bethesda, MD 20892, USA.
Douglas ForrestLaboratory of Endocrinology and Receptor Biology, National Institutes of Health, NIDDK, Bethesda, MD 20892, USA.
Andrii RudenkoDepartment of Biology and Graduate Program, The City College and City University of New York, New York, NY 10031, USA.
In-Jung KimDepartment of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06511, USA in-jung.kim@yale.edu.ORCID 0000-0001-9469-5357
Yale University · USNational Institutes of Health · USCity College of New York · US

Funding

Orphan nuclear receptors and mammalian developmentZIADK047035 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI FORREST, DOUGLAS · 2009 to 2025
$8.6M
Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI In-Jung Kim · 2016 to 2026
$7.1M
Molecular Mechanisms of Visual Circuit Formation between Superior Colliculus and ThalamusR21EY029820 · NEI · YALE UNIVERSITY · PI KIM, IN-JUNG · 2019 to 2020
$461k
NEI NIH HHS P30 EY026878NEI NIH HHS R21 EY029820
6 · The paper itself

Abstract

Developmental control of long-range neuronal connections in the mammalian midbrain remains unclear. We explored the mechanisms regulating target selection of the developing superior colliculus (SC). The SC is a midbrain center that directs orienting behaviors and defense responses. We discovered that a transcription factor, Rorβ, controls establishment of axonal projections from the SC to two thalamic nuclei: the dorsal lateral geniculate nucleus (dLGN) and the lateral posterior nucleus (LP). A genetic strategy used to visualize SC circuits revealed that in control animals Rorβ

Indexed as

AnimalsAnimals, NewbornAxonsEmbryo, MammalianFemaleGeniculate BodiesHEK293 CellsHumansMaleMesencephalonMiceMice, TransgenicNeuronsNuclear Receptor Subfamily 1, Group F, Member 2PregnancySuperior ColliculiNuclear Receptor Subfamily 1, Group F, Member 2Rorb protein, mouseAxon targetingFLP-DOGMidbrainRorβSuperior colliculusThalamus

Identifiers

PMID31332038
PMCPMC6679361
OpenAlexW2963595630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.