Evidence map›Paper›PMID 31332008›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Human species-specific loss of CMP-

Kunio Kawanishi, Chirag Dhar, Raymond Do, Nissi Varki, Philip L S M Gordts, Ajit Varki

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
  2. Article
  3. Gangliosides in molecular interactions and cell regulation.The Journal of biological chemistry · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Hepatic Topology of Glycosphingolipids inAnalytical chemistry · 2024
    Article
  11. Article
  12. Influenza D virus utilizes both 9-Journal of virology · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kunio KawanishiGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA 92093.
Chirag DharGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA 92093.
Raymond DoGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA 92093.
Nissi VarkiGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA 92093.
Philip L S M GordtsGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA 92093; pgordts@ucsd.edu a1varki@ucsd.edu.ORCID 0000-0001-7224-4328
Ajit VarkiGlycobiology Research and Training Center, University of California San Diego, La Jolla, CA 92093; pgordts@ucsd.edu a1varki@ucsd.edu.ORCID 0000-0002-2206-975X
University of California San Diego · US

Funding

BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDSR01GM032373 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARKI, AJIT P · 1985 to 2022
$6.9M
NIGMS NIH HHS R01 GM032373
6 · The paper itself

Abstract

Cardiovascular disease (CVD) events due to atherosclerosis cause one-third of worldwide deaths and risk factors include physical inactivity, age, dyslipidemia, hypertension, diabetes, obesity, smoking, and red meat consumption. However, ∼15% of first-time events occur without such factors. In contrast, coronary events are extremely rare even in closely related chimpanzees in captivity, despite human-like CVD-risk-prone blood lipid profiles, hypertension, and mild atherosclerosis. Similarly, red meat-associated enhancement of CVD event risk does not seem to occur in other carnivorous mammals. Thus, heightened CVD risk may be intrinsic to humans, and genetic changes during our evolution need consideration. Humans exhibit a species-specific deficiency of the sialic acid

Indexed as

AnimalsAtherosclerosisCattleCytokinesDiet, High-FatFemaleHumansHyperglycemiaInflammationMacrophagesMaleMice, Inbred C57BLMixed Function OxygenasesModels, BiologicalPhenotypeReceptors, LDLCMPacetylneuraminate monooxygenaseCytokinesMixed Function OxygenasesN-(O-acetyl)glycoloylneuraminic acidReceptors, LDLSialic AcidsatherosclerosisCMAHcytidine-5′-monophosphate (CMP)-N-acetylneuraminic acid (Neu5Ac) hydroxylase (CMAH)human evolutionN-glycolylneuraminic acid (Neu5Gc)

Identifiers

PMID31332008
PMCPMC6690033
OpenAlexW2962819899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.