Evidence map›Paper›PMID 31332002›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Investigation of the allosteric coupling mechanism in a glutamate transporter homolog via unnatural amino acid mutagenesis.

Erika A Riederer, Francis I Valiyaveetil

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Distinct roles of the NaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
  7. Article
  8. Linking function to global and local dynamics in an elevator-type transporter.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
  10. Mechanisms of ligand binding.Biophysics reviews · 2020
    Review
  11. Article
  12. NaScience advances · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Erika A RiedererProgram in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR 97239.ORCID 0000-0003-1011-6536
Francis I ValiyaveetilProgram in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR 97239 valiyave@ohsu.edu.
Oregon Health & Science University · US

Funding

The structural dynamics of a glutamate transporter homologueR37NS085318 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BOUDKER, OLGA · 2014 to 2020
$4.3M
Probing functional mechanisms in K+ channels using unnatural mutagenesisR01GM087546 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI VALIYAVEETIL, FRANCIS · 2009 to 2022
$4.0M
Using unnatural amino acid mutagenesis to probe a glutamate transporter homologR21NS113561 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI VALIYAVEETIL, FRANCIS · 2019 to 2019
$424k
NIGMS NIH HHS R01 GM087546NINDS NIH HHS R21 NS113561NINDS NIH HHS R37 NS085318
6 · The paper itself

Abstract

Glutamate transporters harness the ionic gradients across cell membranes for the concentrative uptake of glutamate. The sodium-coupled Asp symporter, Glt

Indexed as

Sequence Homology, Amino AcidAllosteric RegulationAmino AcidsAmino Acid Transport System X-AGFluorescenceKineticsModels, MolecularMutagenesisProtein Structure, SecondarySodiumAmino AcidsAmino Acid Transport System X-AGSodiumfluorescenceglutamate transportersunnatural amino acids

Identifiers

PMID31332002
PMCPMC6690018
OpenAlexW2963495477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.