Evidence map›Paper›PMID 31331982›Full record

ArticleLife science alliance2019

Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.

Yuko Matsumura, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliayi Sulidan, Yataro Daigo, Toru Hiraga, Kaoru Mogushi, Nadila Wali, Hiromu Suzuki, Takumi Itoh and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 63 citations in OpenAlex.

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  14. Dual effect of vitamin DBMC cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 2 countries.

Yuko MatsumuraDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Yasuhiko ItoDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Yoshihiro MezawaDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Kaidiliayi SulidanDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Yataro DaigoCenter for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Toru HiragaDepartment of Histology and Cell Biology, Matsumoto Dental University, Nagano, Japan.ORCID 0000-0002-7829-2395
Kaoru MogushiIntractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Nadila WaliDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Hiromu SuzukiDepartment of Molecular Biology, School of Medicine, Sapporo Medical University, Hokkaido, Japan.
Takumi ItohDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.ORCID 0000-0002-6535-1042
Yohei MiyagiMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.
Tomoyuki YokoseDepartment of Pathology, Kanagawa Cancer Center, Yokohama, Japan.ORCID 0000-0002-9403-9592
Satoru ShimizuDepartment of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Atsushi TakanoCenter for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yasuhisa TeraoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Harumi SaekiDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Masayuki OzawaGraduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Masaaki AbeDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Satoru TakedaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Ko OkumuraAtopy Research Center, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Sonoko HabuAtopy Research Center, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Okio HinoDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Kazuyoshi TakedaDivision of Cell Biology, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.ORCID 0000-0002-5539-310X
Michiaki HamadaDepartment of Electrical Engineering and Bioscience, Faculty of Science and Engineering, Waseda University, Tokyo, Japan.ORCID 0000-0001-9466-1034
Akira OrimoDepartment of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan aorimo@juntendo.ac.jp.ORCID 0000-0001-5330-7282
Juntendo University · JPKanagawa Prefectural Hospital Organization · JPShiga University of Medical Science · JPKagoshima University · JPMatsumoto Dental University · JPSapporo Medical University · JPUniversity of Manchester · GBWaseda University · JP

Funding

Cancer Research UK C147/A6058
6 · The paper itself

Abstract

Emerging evidence supports the hypothesis that multicellular tumor clusters invade and seed metastasis. However, whether tumor-associated stroma induces epithelial-mesenchymal plasticity in tumor cell clusters, to promote invasion and metastasis, remains unknown. We demonstrate herein that carcinoma-associated fibroblasts (CAFs) frequently present in tumor stroma drive the formation of tumor cell clusters composed of two distinct cancer cell populations, one in a highly epithelial (E-cadherin

Indexed as

AnimalsAntigens, CDBreast NeoplasmsCadherinsCarcinoembryonic AntigenCell Adhesion MoleculesCell PlasticityCells, CulturedEpithelial-Mesenchymal TransitionFemaleFibroblastsGPI-Linked ProteinsHumansLung NeoplasmsMCF-7 CellsMiceAntigens, CDCadherinsCarcinoembryonic AntigenCDH1 protein, humanCEACAM5 protein, humanCEACAM6 protein, humanCell Adhesion MoleculesGPI-Linked ProteinsZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1

Identifiers

PMID31331982
PMCPMC6653778
OpenAlexW2964261341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.