Evidence map›Paper›PMID 31331976›Full record

ArticleJournal of bacteriology2019

Ambient pH Alters the Protein Content of Outer Membrane Vesicles, Driving Host Development in a Beneficial Symbiosis.

Jonathan B Lynch, Julia A Schwartzman, Brittany D Bennett, Sarah J McAnulty, Mirjam Knop, Spencer V Nyholm, Edward G Ruby

Abstract read
In one paragraph

Article in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. SypC, a symbiont outer membrane vesicle protein, impacts the development of the squid-vibrio partnership.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Outer membrane vesicles inMicrobial cell (Graz, Austria) · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Nocturnal Acidification: A Coordinating Cue in theInternational journal of molecular sciences · 2022
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan B LynchPacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Julia A SchwartzmanDepartment of Medical Microbiology & Immunology, University of Wisconsin, Madison, Wisconsin, USA.
Brittany D BennettPacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Sarah J McAnultyDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
Mirjam KnopDepartment of Molecular Physiology, Zoology, Kiel University, Kiel, Germany.
Spencer V NyholmDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
Edward G RubyPacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA eruby@hawaii.edu.

Funding

Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHRISTOPHER S FRANCKLYN · 2012 to 2026
$58.4M
The Control of Insect Metabolism through Nutrition-based SymbiosisP20GM125508 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Anthony Amend · 2018 to 2026
$21.2M
WATER DISTRIB:PHYSICAL PROPERT:PIZZA &LMPS MOZZARELLA CHEESES:EARLY STAGE MATURP41RR002301 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 1985 to 2011
$13.0M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Vibrio fischeri as a Model for Bacterial ColonizationR37AI050661 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI MARGARET J MC FALL-NGAI, Edward G Ruby · 2018 to 2026
$5.4M
Vibrio fischeri as a model of Bacterial ColonizationR01AI050661 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MC FALL-NGAI, MARGARET J, RUBY, EDWARD G · 2002 to 2016
$5.0M
Vibrio Virulence Determinants in a Benign ColonizationR01OD011024 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MC FALL-NGAI, MARGARET J, RUBY, EDWARD G · 2012 to 2020
$3.9M
Determination of outer membrane vesicle composition and effector activity in the Vibrio fischeri-Euprymna scolopes symbiosisF32GM119238 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI LYNCH, JONATHAN · 2016 to 2018
$174k
NCRR NIH HHS P41 RR002301NIAID NIH HHS R01 AI050661NIAID NIH HHS R37 AI050661NIGMS NIH HHS F32 GM119238NIGMS NIH HHS P20 GM103449NIGMS NIH HHS P20 GM125508NIGMS NIH HHS T32 GM008505NIH HHS R01 OD011024
6 · The paper itself

Abstract

Outer membrane vesicles (OMVs) are continuously produced by Gram-negative bacteria and are increasingly recognized as ubiquitous mediators of bacterial physiology. In particular, OMVs are powerful effectors in interorganismal interactions, driven largely by their molecular contents. These impacts have been studied extensively in bacterial pathogenesis but have not been well documented within the context of mutualism. Here, we examined the proteomic composition of OMVs from the marine bacterium

Indexed as

Aliivibrio fischeriAnimalsBacterial Outer Membrane ProteinsDecapodiformesExtracellular VesiclesGene Expression Regulation, BacterialHost Microbial InteractionsHydrogen-Ion ConcentrationProteomicsSymbiosisUp-RegulationBacterial Outer Membrane Proteinsouter membrane vesiclessquid-Vibrio symbiosisVibrio fischeri

Identifiers

PMID31331976
PMCPMC6755730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.