Evidence map›Paper›PMID 31331961›Full record

ArticleJournal of cell science2019

Synergistic repression of thyroid hyperplasia by cyclin C and Pten.

Jan Jezek, Kun Wang, Ruilan Yan, Antonio Di Cristofano, Katrina F Cooper, Randy Strich

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jan JezekDepartment of Molecular Biology, Graduate School of Biological Sciences, Rowan University, Stratford, NJ 08084, USA.
Kun WangDepartment of Molecular Biology, Graduate School of Biological Sciences, Rowan University, Stratford, NJ 08084, USA.
Ruilan YanDepartment of Molecular Biology, Graduate School of Biological Sciences, Rowan University, Stratford, NJ 08084, USA.
Antonio Di CristofanoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Katrina F CooperDepartment of Molecular Biology, Graduate School of Biological Sciences, Rowan University, Stratford, NJ 08084, USA.ORCID 0000-0003-4619-7534
Randy StrichDepartment of Molecular Biology, Graduate School of Biological Sciences, Rowan University, Stratford, NJ 08084, USA strichra@rowan.edu.ORCID 0000-0003-3346-8972
Rowan University · USAlbert Einstein College of Medicine · US

Funding

Molecular analysis and therapeutic targeting of PI3K signaling in thyroid cancerR01CA128943 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DI CRISTOFANO, ANTONIO · 2009 to 2024
$5.8M
Stress regulated mitochondrial dynamicsR01GM113052 · NIGMS · ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED · PI STRICH, RANDY S · 2014 to 2017
$1.3M
Stress induced signaling and cyclin C regulation in yeastR15GM113196 · NIGMS · ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED · PI COOPER, KATRINA FRANCES · 2015 to 2015
$396k
NCI NIH HHS R01 CA128943NIGMS NIH HHS R01 GM113052NIGMS NIH HHS R15 GM113196
6 · The paper itself

Abstract

The cyclin C-Cdk8 kinase has been identified as both a tumor suppressor and an oncogene depending on the cell type. The genomic locus encoding cyclin C (

Indexed as

AnimalsCell Line, TumorCyclin CCyclin-Dependent Kinase Inhibitor p21MiceMice, KnockoutPTEN PhosphohydrolaseSTAT3 Transcription FactorThyroid NeoplasmsCcnc protein, mouseCdkn1a protein, mouseCyclin CCyclin-Dependent Kinase Inhibitor p21PTEN PhosphohydrolasePten protein, mouseStat3 protein, mouseSTAT3 Transcription FactorMouse knockoutp21p53Thyroid cancer

Identifiers

PMID31331961
PMCPMC6737908
OpenAlexW2905257283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.