ArticleDevelopment (Cambridge, England)2019
Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis.
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Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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Who cites it
34 citing papers in PubMed, 50 citations in OpenAlex.
- Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblasts.Cell reports · 2026Article
- Article
- Prenatal diisononyl phthalate exposure induces the development of pulmonary dysplasia in offspring.Scientific reports · 2026Article
- Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung.Cell reports · 2026Article
- The evolving pathophysiology of bronchopulmonary dysplasia.Physiological reviews · 2026Review
- Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner.BMC medicine · 2025Article
- Cellular imbalance in proximal and distal lung of CFTRMolecular medicine (Cambridge, Mass.) · 2025Article
- Heparan sulfate regulates myofibroblast heterogeneity and function to mediate niche homeostasis during alveolar morphogenesis.Nature communications · 2025Article
- Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification.eLife · 2024Article
- Fingolimod, a sphingosine-1-phosphate receptor modulator, prevents neonatal bronchopulmonary dysplasia and subsequent airway remodeling in a murine model.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification.bioRxiv : the preprint server for biology · 2024Article
- Cell Cross-Talk in Alveolar Microenvironment: From Lung Injury to Fibrosis.American journal of respiratory cell and molecular biology · 2024Review
- Identification of a myofibroblast differentiation program during neonatal lung development.Development (Cambridge, England) · 2024Article
- Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis.Development (Cambridge, England) · 2024Article
- Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRAAmerican journal of respiratory cell and molecular biology · 2024Article
- Hedgehog and Platelet-derived Growth Factor Signaling Intersect during Postnatal Lung Development.American journal of respiratory cell and molecular biology · 2023Article
- Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.Development (Cambridge, England) · 2023Article
- Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell.Molecular and cellular pediatrics · 2023Review
- Treatment with Amniotic Fluid Stem Cell Extracellular Vesicles Promotes Fetal Lung Branching and Cell Differentiation at Canalicular and Saccular Stages in Experimental Pulmonary Hypoplasia Secondary to Congenital Diaphragmatic Hernia.Stem cells translational medicine · 2022Article
- Article
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Authors and funding
14 authors at 4 institutions in 4 countries.
Changgong LiDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA changgon@usc.edu minoo@usc.edu.ORCID 0000-0002-8534-8190
Matt K LeeDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA.
Feng GaoDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA.
Sha WebsterDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA.ORCID 0000-0002-9997-9081
Helen DiDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA.ORCID 0000-0001-9915-4445
Jiang DuanDepartment of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China.ORCID 0000-0002-1455-4202
Chang-Yo YangDepartment of Pediatrics, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan.
Navin BhopalDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA.ORCID 0000-0002-4800-4284
Neil PeinadoDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA.
Gloria PryhuberDepartment of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Susan M SmithDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA.
Zea BorokHastings Center for Pulmonary Research and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Saverio BellusciDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA.
Parviz MinooDepartment of Pediatrics, Division of Newborn Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA 90033, USA changgon@usc.edu minoo@usc.edu.ORCID 0000-0001-8016-8433
University of Southern California · USChang Gung University · TWKunming Medical University · CNUniversity of Rochester Medical Center · US
Funding
Beyond the Barrier: Alveolar Epithelial Cell Biology in Health and DiseaseR35HL135747 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BOROK, ZEA · 2017 to 2023
$6.8MPostnatal Alveolar FormationR01HL143059 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MINOO, PARVIZ MINOO · 2018 to 2021
$2.1MWNT5a Signaling in Stage Specific Alveolar Epithelial Cell DifferentiationR01HL144932 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LI, CHANGGONG, MINOO, PARVIZ MINOO · 2019 to 2022
$2.0MTHE BIOLOGY OF PULMONARY ALVEOLAR FORMATIONR01HL122764 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MINOO, PARVIZ MINOO · 2015 to 2018
$1.6MNHLBI NIH HHS R01 HL122764NHLBI NIH HHS R01 HL143059NHLBI NIH HHS R01 HL144932NHLBI NIH HHS R35 HL135747
Abstract
Postnatal alveolar formation is the most important and the least understood phase of lung development. Alveolar pathologies are prominent in neonatal and adult lung diseases. The mechanisms of alveologenesis remain largely unknown. We inactivated
Indexed as
AdipokinesAnimalsBronchopulmonary DysplasiaCalcium-Binding ProteinsCell DifferentiationCells, CulturedEGF Family of ProteinsElastinExtracellular Matrix ProteinsFibrillin-1HumansMiceMice, KnockoutMyofibroblastsProtein-Lysine 6-OxidasePulmonary AlveoliAdipokinesCalcium-Binding ProteinsEGF Family of ProteinsElastinExtracellular Matrix ProteinsFbn1 protein, mouseFibrillin-1fibulinLox protein, mouseProtein-Lysine 6-OxidaseReceptor, Platelet-Derived Growth Factor alphaRNA, MessengerTgfb1 protein, mouseTransforming Growth Factor beta1Alveolar formationElastogenesisHumanLung developmentMousePdgfraSecondary crest myofibroblast
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.