Evidence map›Paper›PMID 31331912›Full record

ArticleCancer research2019

Time-Resolved MRI Assessment of Convection-Enhanced Delivery by Targeted and Nontargeted Nanoparticles in a Human Glioblastoma Mouse Model.

Zachary R Stephen, Peter A Chiarelli, Richard A Revia, Kui Wang, Forrest Kievit, Chris Dayringer, Mike Jeon, Richard Ellenbogen, Miqin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

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  8. Nanoscale advances · 2023
    Article
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  19. Engineering precision nanoparticles for drug delivery.Nature reviews. Drug discovery · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zachary R Stephen *Department of Materials Science and Engineering, University of Washington, Seattle, Washington.
Peter A Chiarelli *Department of Neurological Surgery, University of Washington, Seattle, Washington.
Richard A Revia *Department of Materials Science and Engineering, University of Washington, Seattle, Washington.ORCID 0000-0002-3469-6582
Kui WangDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington.
Forrest KievitDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington.
Chris DayringerDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington.
Mike JeonDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington.
Richard EllenbogenDepartment of Neurological Surgery, University of Washington, Seattle, Washington. mzhang@u.washington.edu rge@neurosurgery.washington.edu.
Miqin ZhangDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington. mzhang@u.washington.edu rge@neurosurgery.washington.edu.ORCID 0000-0001-8974-1494
University of Washington · USChildren's Hospital of Los Angeles · US

Funding

Multifunctional nanoparticles to improve treatment of human glioblastomaR01CA161953 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2013 to 2017
$1.7M
Nanotechnology and Physical Science Training Program in Cancer ResearchT32CA138312 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2009 to 2013
$1.5M
Bruker Avance III 600 MHz (14T) Wide Bore SpectrometerS10RR029021 · NCRR · UNIVERSITY OF WASHINGTON · PI KUSHMERICK, MARTIN J · 2010 to 2010
$1.0M
Iron Oxide Nanoparticle-Mediated Radiation Delivery for Glioblastoma TreatmentF31CA232546 · NCI · UNIVERSITY OF WASHINGTON · PI REVIA, RICHARD AARON · 2018 to 2019
$73k
NCI NIH HHS F31 CA232546NCI NIH HHS R01 CA161953NCI NIH HHS T32 CA138312NCRR NIH HHS S10 RR029021
6 · The paper itself

Abstract

Convection-enhanced delivery (CED) provides direct access of infusates to brain tumors; however, clinical translation of this technology has not been realized because of the inability to accurately visualize infusates in real-time and lack of targeting modalities against diffuse cancer cells. In this study, we use time-resolved MRI to reveal the kinetics of CED processes in a glioblastoma (GBM) model using iron oxide nanoparticles (NP) modified with a glioma-targeting ligand, chlorotoxin (CTX). Mice bearing orthotopic human GBM tumors were administered a single dose of targeted CTX-conjugated NP (NPCP-CTX) or nontargeted NP (NPCP) via CED. High-resolution T2-weighted, T2*-weighted, and quantitative T2 MRI were utilized to image NP delivery in real time and determined the volume of distribution (V

Indexed as

Drug Delivery SystemsAnimalsApoptosisCell ProliferationContrast MediaConvectionFerric CompoundsGlioblastomaHumansMagnetic Resonance ImagingMiceNanoparticlesNeurotoxinsScorpion VenomsTumor Cells, CulturedXenograft Model Antitumor AssaysChlorotoxinContrast MediaFerric Compoundsferric oxideNeurotoxinsScorpion Venoms

Identifiers

PMID31331912
PMCPMC6744959
OpenAlexW2963621208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.