Evidence map›Paper›PMID 31331911›Full record

ArticleCancer research2019

Selective Targeting of Myoblast Fusogenic Signaling and Differentiation-Arrest Antagonizes Rhabdomyosarcoma Cells.

Valerie A Granados, Usha Avirneni-Vadlamudi, Pooja Dalal, Samuel R Scarborough, Kathleen A Galindo, Priya Mahajan, Rene L Galindo

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Valerie A GranadosDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.
Usha Avirneni-VadlamudiDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.
Pooja DalalDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.
Samuel R ScarboroughDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.
Kathleen A GalindoDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.
Priya MahajanDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Rene L GalindoDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas. rene.galindo@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

MECHANISMS OF DRUG ACTION AND DISPOSITIONT32GM007062 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MANGELSDORF, DAVID J · 1985 to 2020
$7.4M
Defective Myoblast Fusion Signaling in Rhabdomyosarcoma PathogenesisR01CA193339 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GALINDO, RENE L · 2016 to 2021
$1.8M
NCI NIH HHS R01 CA193339NIGMS NIH HHS T32 GM007062
6 · The paper itself

Abstract

Rhabdomyosarcoma (RMS) is an aggressive soft tissue malignancy comprised histologically of skeletal muscle lineage precursors that fail to exit the cell cycle and fuse into differentiated syncytial muscle-for which the underlying pathogenetic mechanisms remain unclear. In contrast to myogenic transcription factor signaling, the molecular machinery that orchestrates the discrete process of myoblast fusion in mammals is poorly understood and unexplored in RMS. The fusogenic machinery in

Indexed as

AnimalsAntineoplastic AgentsCell DifferentiationDrosophilaDrosophila ProteinsErbB ReceptorsGene Expression Regulation, NeoplasticHumansMiceMyoblastsProto-Oncogene Proteins c-aktRhabdomyosarcomaXenograft Model Antitumor AssaysAntineoplastic AgentsDrosophila ProteinsErbB ReceptorsProto-Oncogene Proteins c-akt

Identifiers

PMID31331911
PMCPMC6744982
OpenAlexW2963225701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.