Alterations in connexin 26 protein structure from lethal keratitis-ichthyosis-deafness syndrome mutations A88V and G45E.

Evelyn Lilly, Michael Strickler, Leonard M Milstone, Christopher G Bunick

Abstract readLetter

In one paragraph

Article in Journal of dermatological science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Differential transcriptomic host responses in the early phase of viral and bacterial infections in human lung tissue explants ex vivo.Respiratory research · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Evelyn LillyDepartment of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Michael StricklerYale Center for Research Computing, Yale University, New Haven, CT, 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.

Leonard M MilstoneDepartment of Dermatology, Yale University, New Haven, CT, 06520, USA.

Christopher G BunickDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA; Department of Dermatology, Yale University, New Haven, CT, 06520, USA. Electronic address: christopher.bunick@yale.edu.

Funding

Training in Investigative DermatologyT32AR007016 · NIAMS · YALE UNIVERSITY · PI KEITH A CHOATE, MICHAEL GIRARDI · 1986 to 2026

$7.8M

Determining Structure and Function of Human Skin Barrier Proteins Using X-ray CrystallographyK08AR070290 · NIAMS · YALE UNIVERSITY · PI BUNICK, CHRISTOPHER GERARD · 2016 to 2020

$754k

NIAMS NIH HHS K08 AR070290NIAMS NIH HHS T32 AR007016

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carbon DioxideConnexin 26ConnexinsCrystallography, X-RayGenes, LethalHumansKeratitisModels, MolecularMutationProtein StabilityProtein Structure, QuaternaryThermodynamicsCarbon DioxideConnexin 26ConnexinsGJB2 protein, human

Identifiers

PMID31331740

DOI10.1016/j.jdermsci.2019.07.002

PMCPMC7263394

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.