ArticleMicrobial cell factories2019
Optimized medium via statistical approach enhanced threonine production by Pediococcus pentosaceus TL-3 isolated from Malaysian food.
Article in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Optimization of fermentation medium for advancing postbiotic antibacterial activity.AMB Express · 2026Article
- Efficient Assessment and Optimisation of Medium Components Influencing Extracellular Xylanase Production byInternational journal of molecular sciences · 2025Article
- l-Threonine production from whey and fish hydrolysate byHeliyon · 2023Article
- Alternative culture medium design for biomass production of autochthonous meat starter Latilactobacillus sakei sp. sakei ACU-2.Scientific reports · 2023Article
- Synthesis and characterization of CuEnvironmental science and pollution research international · 2021Article
- A refined medium to enhance the antimicrobial activity of postbiotic produced by Lactiplantibacillus plantarum RS5.Scientific reports · 2021Article
- Biotechnological Innovations and Therapeutic Application of Pediococcus and Lactic Acid Bacteria: The Next-Generation Microorganism.Frontiers in bioengineering and biotechnology · 2021Review
- Nematicidal Activity of Cyclopiazonic Acid Derived FromFrontiers in microbiology · 2021Article
- Enhancement of Versatile Extracellular Cellulolytic and Hemicellulolytic Enzyme Productions byMolecules (Basel, Switzerland) · 2020Article
- Rapid Evaluation and Optimization of Medium Components Governing Tryptophan Production byMolecules (Basel, Switzerland) · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThreonine is an essential amino acid that is extensively used in livestock industry as feed supplement due to its pronounced effect in improving the growth performance of animals. Application of genetically engineered bacteria for amino acid production has its share of controversies after eosinophils myalgia syndrome outbreak in 1980s. This has urged for continuous search for a food grade producer as a safer alternative for industrial amino acid production. Lactic acid bacteria (LAB) appear as an exceptional candidate owing to their non-pathogenic nature and reputation of Generally Recognized as Safe (GRAS) status. Recently, we have identified a LAB, Pediococcus pentosaceus TL-3, isolated from Malaysian food as a potential threonine producer. Thus, the objective of this study was to enhance the threonine production by P. pentosaceus TL-3 via optimized medium developed by using Plackett-Burman design (PBD) and central composite design (CCD).
resultsMolasses, meat extract, (NH
conclusionsThis study has revealed the potential of P. pentosaceus TL-3 as a safer alternative to produce threonine. Additionally, the current study has identified the key medium components affecting the production of threonine by P. pentosaceus TL-3, followed by optimization of their concentrations by means of statistical approach. The findings of this study could act as a guideline for the future exploration of amino acid production by LAB.
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