Evidence map›Paper›PMID 31331372›Full record

ArticleTrials2019

High-flow nasal therapy versus noninvasive ventilation in COPD patients with mild-to-moderate hypercapnic acute respiratory failure: study protocol for a noninferiority randomized clinical trial.

Andrea Cortegiani, Federico Longhini, Annalisa Carlucci, Raffaele Scala, Paolo Groff, Andrea Bruni, Eugenio Garofalo, Maria Rita Taliani, Uberto Maccari, Luigi Vetrugno and 7 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03370666 nacompletednot on this map

High Flow Nasal Therapy Versus Noninvasive Ventilation in Mild to Moderate Acute Hypercapnic Respiratory Failure: A Non-inferiority Randomized Trial

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Policlinico Paolo Giaccone PalermoRan2018 to 2020Enrolled80ConditionsCOPD ExacerbationArmsHFNT, NIV
NCT06257667 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Randomized Controlled Trial to Investigate the Effect of High Flow Nasal Cannula Treatment on Carbon Dioxide-levels in COPD- Patients With Acute Hypercapnic Respiratory Failure, Using Either OptiflowTM or Optiflow+DuetTM Nasal Cannula

TypeinterventionalSponsorAalborg University HospitalRan2024 to 2026Enrolled138ConditionsHypercapnic Respiratory Failure, COPDArmsRespiratory Support
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Andrea CortegianiDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Via del vespro 129, 90127, Palermo, Italy. andrea.cortegiani@unipa.it.ORCID http://orcid.org/0000-0003-1416-9993
Federico LonghiniIntensive Care Unit, Department of Medical and Surgical Sciences, University Hospital Mater Domini, Magna Graecia University, Catanzaro, Italy.
Annalisa CarlucciPulmonary Rehabilitation Unit, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
Raffaele ScalaPulmonology and Respiratory Intensive Care Unit, S. Donato Hospital, Arezzo, Italy.
Paolo GroffEmergency Department, "S. Maria della Misericordia" Hospital, Perugia, Italy.
Andrea BruniIntensive Care Unit, Department of Medical and Surgical Sciences, University Hospital Mater Domini, Magna Graecia University, Catanzaro, Italy.
Eugenio GarofaloIntensive Care Unit, Department of Medical and Surgical Sciences, University Hospital Mater Domini, Magna Graecia University, Catanzaro, Italy.
Maria Rita TalianiEmergency Department, "S. Maria della Misericordia" Hospital, Perugia, Italy.
Uberto MaccariPulmonology and Respiratory Intensive Care Unit, S. Donato Hospital, Arezzo, Italy.
Luigi VetrugnoDepartment of Anaesthesia and Intensive Care, University of Udine, Udine, Italy.
Enrico LupiaEmergency Department, "Città della Salute e della Scienza" University Hospital, Torino, Italy.
Giovanni MisseriDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Via del vespro 129, 90127, Palermo, Italy.
Vittoria ComelliniDepartment of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
Antonino GiarratanoDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Via del vespro 129, 90127, Palermo, Italy.
Stefano NavaDepartment of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
Paolo NavalesiIntensive Care Unit, Department of Medical and Surgical Sciences, University Hospital Mater Domini, Magna Graecia University, Catanzaro, Italy.
Cesare GregorettiDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Via del vespro 129, 90127, Palermo, Italy.
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · ITMagna Graecia University · ITAzienda Ospedaliera di Perugia · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITOspedale San Donato · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITIstituti Clinici Scientifici Maugeri · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNoninvasive ventilation (NIV) is indicated to treat respiratory acidosis due to exacerbation of chronic obstructive pulmonary disease (COPD). Recent nonrandomized studies also demonstrated some physiological effects of high-flow nasal therapy (HFNT) in COPD patients. We designed a prospective, unblinded, multicenter, randomized controlled trial to assess the noninferiority of HFNT compared to NIV with respect to the reduction of arterial partial pressure of carbon dioxide (PaCO

methodsWe will enroll adult patients with acute hypercapnic respiratory failure, as defined by arterial pH between 7.25 and 7.35 and PaCO DISCUSSION: HFNT is more comfortable than NIV in COPD patients recovering from an episode of exacerbation. If HFNT would not be inferior to NIV, HFNT could be considered as an alternative to NIV to treat COPD patients with mild-to-moderate respiratory acidosis.

trial registrationClinicalTrials.gov, NCT03370666 . Registered on December 12, 2017.

Indexed as

Noninvasive VentilationAcute DiseaseEquivalence Trials as TopicHumansHypercapniaItalyLungMulticenter Studies as TopicOxygen Inhalation TherapyProspective StudiesPulmonary Disease, Chronic ObstructiveRespiratory InsufficiencyTime FactorsTreatment OutcomeAcute respiratory failureCarbon dioxideChronic obstructive pulmonary diseaseEmergency departmentHigh-flow oxygen therapy through nasal cannulaIntensive care unitNoninvasive ventilation

Identifiers

PMID31331372
PMCPMC6647141
OpenAlexW2962755430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.