ArticleJournal of psychopharmacology (Oxford, England)2020
Altered neural dynamics in occipital cortices serving visual-spatial processing in heavy alcohol users.
Article in Journal of psychopharmacology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Bayesian Spatiotemporal Wombling.Journal of the American Statistical Association · 2026Article
- Changes in resting-state brain function in chronic alcohol users based on degree centrality.The Journal of international medical research · 2025Article
- Painting psychosis: an empirical investigation of the self-portraits of Edvard Munch.Frontiers in psychiatry · 2025Article
- Neurocognitive Markers during Maximum Alcohol Use in Late Adolescence as Predictors of Change in Later Drinking Behaviors.Mental health science · 2024Article
- The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics.Human brain mapping · 2022Article
- Occipital neural dynamics in cannabis and alcohol use: independent effects of addiction.Scientific reports · 2021Article
- Children with Cerebral Palsy Have Altered Occipital Cortical Oscillations during a Visuospatial Attention Task.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Pubertal Testosterone Tracks the Developmental Trajectory of Neural Oscillatory Activity Serving Visuospatial Processing.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Neural oscillatory dynamics serving abstract reasoning reveal robust sex differences in typically-developing children and adolescents.Developmental cognitive neuroscience · 2020Article
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4 authors.
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Abstract
backgroundVisual-spatial processing deficits have been previously linked to heavy alcohol use, but the underlying neurological mechanisms are poorly understood. Neuroimaging studies have shown alcohol-related aberrations in occipital cortices that appear to be associated with these neuropsychological deficits in visual-spatial processing, however the neural dynamics underlying this altered processing remains unknown.
methodsTwenty-three adults with high scores on the Alcohol Use Disorders Identification Test - Consumption (male: ⩾5, female: ⩾4) were compared to 30 demographically-matched controls with low Alcohol Use Disorders Identification Test - Consumption scores (⩽2). All participants completed a visual-spatial processing task while undergoing high-density magnetoencephalography. Time-frequency windows of interest were determined using a data-driven method, and spectrally-specific neural activity was imaged using a beamforming approach. Permutation testing of peak voxel time series was then used to statistically compare across groups.
resultsParticipants with heavy alcohol use responded slower on the task and their performance was more variable. The magnetoencephalography data indicated strong theta (4-8 Hz), alpha (10-16 Hz), and gamma (62-72 Hz) responses in posterior brain regions across both groups. Following voxel time-series extraction, significant group differences were found in the left and right visual association cortices from about 375-550 ms post-stimulus, such that adults with heavy alcohol use had blunted alpha responses compared to controls.
conclusionIndividuals with heavy alcohol use exhibited aberrant occipital alpha activity during visual-spatial processing. These data are the first to show spectrally-specific differences during visual-spatial processing related to heavy alcohol use, and highlight alcohol's effect on systems-level neural activity.
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