ArticleMolecules (Basel, Switzerland)2019
Multicomponent Synthesis of Polyphenols and their in vitro Evaluation as Potential β-Amyloid Aggregation Inhibitors.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Design strategies, structural insights, and biological potential of amyloid-beta inhibitors in Alzheimer's disease.Molecular diversity · 2026Review
- Multicomponent Hosomi-Sakurai reaction on chiral, bio-based, alcohols.RSC advances · 2025Article
- Natural tea polyphenol functionalized graphene anode for simultaneous power production and degradation of methyl orange dye in microbial fuel cells.RSC advances · 2024Article
- Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies.Beilstein journal of organic chemistry · 2024Review
- The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling.Antioxidants & redox signaling · 2023Review
- Synthesis, Photoisomerization, Antioxidant Activity, and Lipid-Lowering Effect of Ferulic Acid and Feruloyl Amides.Molecules (Basel, Switzerland) · 2020Article
- Special Issue: From Natural Polyphenols to Synthetic Bioactive Analogues.Molecules (Basel, Switzerland) · 2020Article
- Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid.Frontiers in chemistry · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
While plant polyphenols possess a variety of biological properties, exploration of chemical diversity around them is still problematic. Here, an example of application of the Ugi multicomponent reaction to the combinatorial assembly of artificial, yet "natural-like", polyphenols is presented. The synthesized compounds represent a second-generation library directed to the inhibition of β-amyloid protein aggregation. Chiral enantiopure compounds, and polyphenol-β-lactam hybrids have been prepared too. The biochemical assays have highlighted the importance of the key pharmacophores in these compounds. A lead for inhibition of aggregation of truncated protein AβpE3-42 was selected.
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Registered trials
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