Evidence map›Paper›PMID 31331110›Full record

ArticleMarine drugs2019

Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge

Ram P Neupane, Stephen M Parrish, Jayanti Bhandari Neupane, Wesley Y Yoshida, M L Richard Yip, James Turkson, Mary Kay Harper, John D Head, Philip G Williams

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  4. Marine drugs · 2022
    Review
  5. Review
  6. Review
  7. Review
  8. Towards Knowledge Maintenance in Scientific Digital Libraries with the Keystone Framework.Proceedings of the ... ACM/IEEE Joint Conference on Digital Libraries. ACM/IEEE Joint Conference on Digital Libraries · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ram P NeupaneDepartment of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Stephen M ParrishDepartment of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Jayanti Bhandari NeupaneDepartment of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Wesley Y YoshidaDepartment of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
M L Richard YipUniversity of Hawaii Cancer Center, Honolulu, HI 96813, USA.
James TurksonUniversity of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Mary Kay HarperDepartment of Medicinal Chemistry, University of Utah, College of Pharmacy, Salt Lake City, UT 84112, USA.
John D HeadDepartment of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Philip G WilliamsDepartment of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA. philipwi@hawaii.edu.
University of Hawaiʻi at Mānoa · USUniversity of Utah · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
STAT3, G6PD and TrxR as underlying mechanisms for antitumor responses tohirsutinolidesR01CA208851 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI TURKSON, JAMES K · 2017 to 2021
$2.9M
Capture the Inhibitor: Affinity Approaches to the Discovery of Secretase LeadsR01AG039468 · NIA · UNIVERSITY OF HAWAII AT MANOA · PI WILLIAMS, PHILIP · 2011 to 2014
$1.1M
National Science Foundation 1532310National Science Foundation CH E9974921NCI NIH HHS P30 CA071789NCI NIH HHS R01CA208851NIA NIH HHS R01AG039468U.S. Department of Defense W911NF-04-1-0344
6 · The paper itself

Abstract

Several known sesquiterpenoid quinones and quinols (

Indexed as

Amyloid Precursor Protein SecretasesAnimalsAntineoplastic AgentsAspartic Acid EndopeptidasesCell Line, TumorDrug Screening Assays, AntitumorEnzyme InhibitorsGliomaHawaiiHeterocyclic CompoundsHumansHydroquinonesMolecular StructurePancreatic NeoplasmsPoriferaQuinonesAmyloid Precursor Protein SecretasesAntineoplastic AgentsAspartic Acid EndopeptidasesBACE1 protein, humanEnzyme InhibitorsHeterocyclic CompoundsHydroquinonesQuinonesSesquiterpenes11-membered heterocycleBACE1Dactylospongia elegansDFT computationshuman gliomahuman pancreatic carcinomasesquiterpenoid quinones

Identifiers

PMID31331110
PMCPMC6669564
OpenAlexW2964202054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.