ReviewJournal of clinical medicine2019
How to Diagnose and Treat Local Allergic Rhinitis: A Challenge for Clinicians.
Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Different Development Forms of Local Allergic Rhinitis towards Birch.BioMed research international · 2020Trial
- Timothy Grass Pollen-Specific Immunoglobulin E in Nasal Secretions During Natural Allergen Exposure and After a Nasal Provocation Test in Patients with Suspected Local Allergic Rhinitis.Advances in respiratory medicine · 2026Article
- Dust Mite-Specific IgE in Nasal Lavage Fluid During Natural Allergen Exposure and After Nasal Provocation Test in Subjects with Suspected Local Allergic Rhinitis.Life (Basel, Switzerland) · 2025Article
- A Unified Pathogenesis of Allergic Diseases; The Protein-Homeostasis-System Hypothesis.International journal of molecular sciences · 2025Review
- Evaluation on the clinical findings and allergological factors of local allergic conjunctivitis and non-local allergic conjunctivitis.Scientific reports · 2025Article
- Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity.Journal of asthma and allergy · 2025Article
- [Immunoglobulin E in nasal secretions].HNO · 2024Review
- Local Allergic Rhinitis-A Challenge for Allergology and Otorhinolaryngology Cooperation (Scoping Review).Life (Basel, Switzerland) · 2024Review
- Role of autophagy and mitophagy of group 2 innate lymphoid cells in allergic and local allergic rhinitis.The World Allergy Organization journal · 2024Article
- Distributional Characteristics Analysis of Allergens in Patients with Allergic Rhinitis in Southern Fujian Province, China.Journal of asthma and allergy · 2024Article
- Challenges in Local Allergic Rhinitis Diagnosis, Management, and Research: Current Concepts and Future Perspectives.Medicina (Kaunas, Lithuania) · 2023Review
- The aspects of local allergic rhinitis in Polish children and adolescents.Postepy dermatologii i alergologii · 2023Article
- Allergen challenge tests in allergen immunotherapy: State of the art.Allergologie select · 2023Review
- Omalizumab added to allergen immunotherapy increased the effect of therapy in patients with severe local allergic rhinitis.Human vaccines & immunotherapeutics · 2022Article
- Neuronal-Immune Cell Units in Allergic Inflammation in the Nose.International journal of molecular sciences · 2022Review
- The Role of Allergen-Specific Immunotherapy in ENT Diseases: A Systematic Review.Journal of personalized medicine · 2022Review
- The Role of IgE in Upper and Lower Airway Disease: More Than Just Allergy!Clinical reviews in allergy & immunology · 2022Review
- Gold standard diagnostic algorithm for the differential diagnosis of local allergic rhinitis.Postepy dermatologii i alergologii · 2022Review
- Long-Term Exposure to Sulfur Dioxide Before Sensitization Decreased the Production of Specific IgE in HDM-Sensitized Allergic Rhinitis Mice.Journal of inflammation research · 2022Article
- Management of allergic rhinitis with leukotriene receptor antagonists versus selective H1-antihistamines: a meta-analysis of current evidence.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Chronic rhinitis is a very common disease that can be divided in various phenotypes. Historically, the condition has been classified into the allergic rhinitis (AR) and non-allergic non-infectious rhinitis (NAR) forms, based on the results of the classical biomarkers of atopy: skin prick test and serum allergen-specific IgE However, this classification does not reflect the complexity of the rhinitis syndrome, as illustrated by the existence of non-atopic rhinitis patients who display a nasal reactivity to environmental allergens. This new phenotype has been termed local allergic rhinitis (LAR) and can be only recognized if an additional test such as the nasal allergen challenge (NAC) is integrated in the diagnostic algorithm for chronic rhinitis. Recent data shows that the NAC is a very safe and reliable technique ready for the clinical practice. LAR is a differentiated rhinitis phenotype which often commences during childhood and quickly progresses towards a clinical worsening and the association of comorbidities in other mucosal organs. Recent evidence supports the existence of a bronchial counterpart of LAR (local allergic asthma), which highlights the pathophysiological links between the upper and lower airways and reinforces the united airways concept. Importantly, several controlled studies have demonstrated the ability of allergen immunotherapy to control LAR symptoms while the therapy is being administered. This review emphasizes the need to implement the NAC in the clinical practice in order to facilitate the recognition of LAR patients, allowing for an early prescription of specific therapies with disease-modifying potential.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.