ArticleMaterials (Basel, Switzerland)2019
Induction of Osteogenic Differentiation of Mesenchymal Stem Cells by Bioceramic Root Repair Material.
Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Physicochemical Characterization of a Strontium Silicate-Based Root Canal Sealer Compared with Two Conventional Sealers.Journal of functional biomaterials · 2026Article
- Evaluating osteogenic potential of a 3D-printed bioceramic-based scaffold for critical-sized defect treatment: an in vivo and in vitro investigation.In vitro cellular & developmental biology. Animal · 2024Article
- BioceramicHistology and histopathology · 2024Review
- Evaluation of the genotoxicity, cytotoxicity, and bioactivity of calcium silicate-based cements.BMC oral health · 2024Article
- Root-filling materials for endodontic surgery: biological and clinical aspects.Biomaterial investigations in dentistry · 2024Review
- Characterisation of the Bioactivity and the Solubility of a New Root Canal Sealer.International dental journal · 2023Article
- Effect of biodentine coated with emdogain on proliferation and differentiation of human stem cells from the apical papilla.Molecular biology reports · 2022Article
- Antimicrobial and Antibiofilm Properties of Bioceramic Materials in Endodontics.Materials (Basel, Switzerland) · 2021Review
- Physicochemical Properties of Two Generations of MTA-Based Root Canal Sealers.Materials (Basel, Switzerland) · 2021Article
- Review
- Biocompatibility and Bioactivity of Set Direct Pulp Capping Materials on Human Dental Pulp Stem Cells.Materials (Basel, Switzerland) · 2020Article
- Response of periodontal ligament stem cells to lipopolysaccharide and calcium silicate-based materials.Brazilian dental journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
This study aimed to evaluate the osteogenic activity of Endosequence Root Repair Material (ERRM) putty using rat mesenchymal stem cells (MSCs). The extract of set ERRM and ProRoot-mineral trioxide aggregate (MTA) (control) was cocultured with rat MSCs and incubated for one, three, and seven days. The cell viability and proliferation were assessed. A quantitative real-time polymerase chain reaction for bone morphogenetic protein-2 (BMP-2), alkaline phosphatase, bone sialoprotein, and osteocalcin gene expression was performed. Both materials enhanced cell viability and proliferation, which increased over time. On day seven, the cells treated with either material exhibited significantly greater cell viability compared with control untreated cells. MSCs treated with either material showed deeper alkaline phosphatase staining after three days compared to control untreated cells. Treated MSCs also exhibited upregulation of the gene expression of bone morphogenetic protein-2, alkaline phosphatase, bone sialoprotein, and osteocalcin. Both ERRM and ProRoot-MTA enhance the osteogenic differentiation of MSCs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.