ArticlePolymers2019
Chitosan/Glycosaminoglycan Scaffolds: The Role of Silver Nanoparticles to Control Microbial Infections in Wound Healing.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Integrating silver nanomaterials in wound healing: from physicochemical properties to clinical translation.Journal of nanobiotechnology · 2026Review
- Marine-Derived Polysaccharide Nanofibers for Wound Healing: Mechanistic Rationale, Biofabrication Strategies, and Translational Barriers.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Development of Tailored Composite Biopolymer Film Formulations Using Minimally Refined Chitosan from American Lobster (Polymers · 2025Article
- Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal-Organic Frameworks Combined with S- or N-Doped Carbon Dots.Pharmaceutics · 2024Article
- Reinforcing decellularized small intestine submucosa with cellulose acetate nanofibrous and silver nanoparticles as a scaffold for wound healing applications.Molecular biology reports · 2024Article
- Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing.International journal of molecular sciences · 2024Review
- Antimicrobial Activity of Chitosan Scaffold Loaded with Soluble Factors of Different Probiotic Strains Against Multidrug ResistantIranian journal of biotechnology · 2024Article
- Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors.ACS omega · 2023Review
- Review
- Nanoclay-Doped Electrospun Nanofibers for Tissue Engineering: Investigation on the Structural Modifications in Physiological Environment.International journal of nanomedicine · 2023Article
- Antimicrobial Activity of Blow Spun PLA/Gelatin Nanofibers Containing Green Synthesized Silver Nanoparticles against Wound Infection-Causing Bacteria.Bioengineering (Basel, Switzerland) · 2022Article
- Recent Advances in Silver Nanoparticles Containing Nanofibers for Chronic Wound Management.Polymers · 2022Review
- Chitosans and Nanochitosans: Recent Advances in Skin Protection, Regeneration, and Repair.Pharmaceutics · 2022Review
- Biosynthesis and Characterization of Extracellular Silver Nanoparticles fromMolecules (Basel, Switzerland) · 2021Article
- Hyaluronic Acid-Silver Nanocomposites and Their Biomedical Applications: A Review.Materials (Basel, Switzerland) · 2021Review
- Smart Device for Biologically Enhanced Functional Regeneration of Osteo-Tendon Interface.Pharmaceutics · 2021Article
- Marine Polysaccharides for Wound Dressings Application: An Overview.Pharmaceutics · 2021Review
- Biomaterials for Soft Tissue Repair and Regeneration: A Focus on Italian Research in the Field.Pharmaceutics · 2021Review
- Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes.Nanomaterials (Basel, Switzerland) · 2021Article
- Electrospun Scaffolds in Periodontal Wound Healing.Polymers · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous wounds represent a major issue in medical care, with approximately 300 million chronic and 100 million traumatic wound patients worldwide, and microbial infections slow the healing process. The aim of this work was to develop electrospun scaffolds loaded with silver nanoparticles (AgNPs) to enhance cutaneous healing, preventing wound infections. AgNPs were directly added to polymeric blends based on chitosan (CH) and pullulan (PUL) with hyaluronic acid (HA) or chondroitin sulfate (CS) to be electrospun obtaining nanofibrous scaffolds. Moreover, a scaffold based on CH and PUL and loaded with AgNPs was prepared as a comparison. The scaffolds were characterized by chemico-physical properties, enzymatic degradation, biocompatibility, and antimicrobial properties. All the scaffolds were based on nanofibers (diameters about 500 nm) and the presence of AgNPs was evidenced by TEM and did not modify their morphology. The scaffold degradation was proven by means of lysozyme. Moreover, the AgNPs loaded scaffolds were characterized by a good propensity to promote fibroblast proliferation, avoiding the toxic effect of silver. Furthermore, scaffolds preserved AgNP antimicrobial properties, although silver was entrapped into nanofibers. Chitosan/chondroitin sulfate scaffold loaded with AgNPs demonstrated promotion of fibroblast proliferation and to possess antimicrobial properties, thus representing an interesting tool for the treatment of chronic wounds.
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