Evidence map›Paper›PMID 31330887›Full record

ArticleCells2019

Copine A Interacts with Actin Filaments and Plays a Role in Chemotaxis and Adhesion.

Matthew J Buccilli, April N Ilacqua, Mingxi Han, Andrew A Banas, Elise M Wight, Hanqian Mao, Samantha P Perry, Tasha S Salter, David R Loiselle, Timothy A J Haystead and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Loss of Copine D Leads to Ras Activation inbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Adhesion ofFrontiers in cell and developmental biology · 2022
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Matthew J BuccilliDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
April N IlacquaDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Mingxi HanDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Andrew A BanasDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Elise M WightDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Hanqian MaoDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Samantha P PerryDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Tasha S SalterDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
David R LoiselleDepartment of Pharmacology and Cancer, Duke University Medical Center, Durham, NC 27708, USA.
Timothy A J HaysteadDepartment of Pharmacology and Cancer, Duke University Medical Center, Durham, NC 27708, USA.
Cynthia K DamerDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA. damer1ck@cmich.edu.ORCID 0000-0003-2059-5294
Central Michigan University · USDuke Medical Center · US

Funding

The role of copines in the regulation of the actin cytoskeleton and membrane traffickingR15GM078089 · NIGMS · CENTRAL MICHIGAN UNIVERSITY · PI CYNTHIA K DAMER · 2008 to 2026
$1.6M
NIGMS NIH HHS R15 GM078089
6 · The paper itself

Abstract

Copines make up a family of calcium-dependent, phospholipid-binding proteins found in numerous eukaryotic organisms. Copine proteins consist of two C2 domains at the N-terminus followed by an A domain similar to the von Willebrand A domain found in integrins. We are studying copine protein function in the model organism,

Indexed as

ChemotaxisActin CytoskeletonCalciumCarrier ProteinsCell AdhesionDictyosteliumProtein BindingProtozoan ProteinsCalciumCarrier ProteinscopineProtozoan ProteinsactinadhesioncalciumcAMPchemotaxiscopineDictyostelium

Identifiers

PMID31330887
PMCPMC6679068
OpenAlexW2963564202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.