Evidence map›Paper›PMID 31330869›Full record

ArticleInternational journal of molecular sciences2019

Vitamin D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/IRF3 Signaling Pathway In Vivo and In Vitro.

Ye Zhao, Zhiming Ran, Qin Jiang, Ningming Hu, Bing Yu, Li Zhu, Linyuan Shen, Shunhua Zhang, Lei Chen, Hong Chen and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ye ZhaoCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China. zhye@sicau.edu.cn.
Zhiming RanKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Ya'an 625014, China.
Qin JiangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Ningming HuKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Ya'an 625014, China.
Bing YuKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Ya'an 625014, China.
Li ZhuCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Linyuan ShenCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Shunhua ZhangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Lei ChenCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Hong ChenKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Ya'an 625014, China.
Jun JiangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Daiwen ChenKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Ya'an 625014, China. dwchen@sicau.edu.cn.ORCID 0000-0002-8351-7421
Sichuan Agricultural University · CN

Funding

National Natural Science Foundation of China 31601952
6 · The paper itself

Abstract

(1) Background: Vitamin D (VD) plays a vital role in anti-viral innate immunity. However, the role of VD in anti-rotavirus and its mechanism is still unclear. The present study was performed to investigate whether VD alleviates rotavirus (RV) infection through a microRNA-155-5p (miR-155-5p)-mediated regulation of TANK-binding kinase 1 (TBK1)/interferon regulatory factors 3 (IRF3) signaling pathway in vivo and in vitro. (2) Methods: The efficacy of VD treatment was evaluated in DLY pig and IPEC-J2. Dual-luciferase reporter activity assay was performed to verify the role of miR-155-5p in 1α,25-dihydroxy-VD

Indexed as

AnimalsGene Expression RegulationInterferon Regulatory Factor-3MicroRNAsProtein Serine-Threonine KinasesRotavirusRotavirus InfectionsSignal TransductionSwineSwine DiseasesVirus ReplicationVitamin DInterferon Regulatory Factor-3MicroRNAsProtein Serine-Threonine KinasesVitamin DIPEC-J2microRNA-155-5ppigsrotavirusTBK1/IRF3VD

Identifiers

PMID31330869
PMCPMC6678911
OpenAlexW2962979045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.