Evidence map›Paper›PMID 31330513›Full record

Trial reportJournal of innate immunity2020

Survivin Impairs the Apoptotic Machinery in CD4+ T Cells of Patients with Ulcerative Colitis.

Bai-Sui Feng, Na Ma, Yuan-Yi Zhang, Han Gao, Cui Zhang, Gengfeng Li, Zhanju Liu, Yisheng Feng, Hai-Qiong Yu, Liang Xiao and 2 more

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of innate immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Once upon a Time.Journal of innate immunity · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Bai-Sui FengDepartment of Gastroenterology, Second Hospital, Zhengzhou University, Zhengzhou, China.
Na MaDepartment of Gastroenterology, Second Hospital, Zhengzhou University, Zhengzhou, China.
Yuan-Yi ZhangResearch Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Han GaoDepartment of Gastroenterology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Cui ZhangDepartment of Gastroenterology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Gengfeng LiDepartment of Gastroenterology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Zhanju LiuDepartment of Gastroenterology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Yisheng FengDepartment of Colorectal Surgery, Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Kunshan City, China.
Hai-Qiong YuDepartment of Respirology, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Liang XiaoMetagenomic Institute, BGI Research GeneBank, Shenzhen, China.
Zhi-Gang LiuResearch Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Ping-Chang YangResearch Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen, China, pcy2356@163.com.
Shenzhen University · CNShanghai Tenth People's Hospital · CNSecond Affiliated Hospital of Zhengzhou University · CNBGI ResearchShanghai University of Traditional Chinese Medicine · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe increase in CD4+ T cell infiltration and overproduction of CD4+ T cell-associated cytokines have been observed in the inflamed colon mucosa of patients with ulcerative colitis (UC); the underlying mechanisms are not fully understood. Survivin plays a critical role in the interference with apoptotic machinery. This study aims to elucidate the role of survivin in the interference with the apoptotic machinery in CD4+ T cells of UC patients.

methodsPeripheral blood samples were collected from UC patients (UC group) and healthy subjects (healthy group). The apoptotic status in CD4+ T cells was analyzed by flow cytometry.

resultsWe observed that the expression of survivin was significantly higher in CD4+ T cells of UC patients than in healthy subjects. UC CD4+ T cells were resistant to apoptosis induction. A complex of survivin and c-Myc, the transcription factor of FasL, was detected in CD4+ T cells in UC patients, which prevented the binding of c-Myc to the FasL promoter and interfered with the expression of FasL. Increased expression of survivin prevented the activation-induced CD4+ T cells from apoptosis.

conclusionsThe data indicate that UC CD4+ T cells express high levels of survivin, which impairs the apoptotic machinery in CD4+ T cells and prevents the activation-induced CD4+ T cell apoptosis. Therefore, target therapy against survivin has translational potential in the treatment of UC patients.

Indexed as

AdultApoptosisCD4-Positive T-LymphocytesColitis, UlcerativeFas Ligand ProteinFemaleHumansMaleProto-Oncogene Proteins c-mycSurvivinBIRC5 protein, humanFASLG protein, humanFas Ligand ProteinMYC protein, humanProto-Oncogene Proteins c-mycSurvivinApoptosisColitisImmunityIntestineLymphocyte

Identifiers

PMID31330513
PMCPMC7265744
OpenAlexW2963387589

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.