ArticleCellular and molecular gastroenterology and hepatology2019
Mist1 Expression Is Required for Paneth Cell Maturation.
Article in Cellular and molecular gastroenterology and hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Paneth cell-derived Notch ligands DLL1 and DLL4 are crucial for intestinal crypt base stem cells.bioRxiv : the preprint server for biology · 2026Article
- Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell.Cell stem cell · 2025Article
- MIST1 regulates endoplasmic reticulum stress-induced hepatic apoptosis as a candidate marker of fatty liver disease progression.Cell death & disease · 2024Article
- Article
- NMP4, an Arbiter of Bone Cell Secretory Capacity and Regulator of Skeletal Response to PTH Therapy.Calcified tissue international · 2023Review
- Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro.Nature cell biology · 2023Article
- Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Ptpn2: A Critical Regulator of Paneth Cell Homeostasis.Cellular and molecular gastroenterology and hepatology · 2023Article
- Paneth cell maturation is related to epigenetic modification during neonatal-weaning transition.Histochemistry and cell biology · 2022Article
- Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- NF-κB determines Paneth versus goblet cell fate decision in the small intestine.Development (Cambridge, England) · 2021Article
- ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program.EMBO reports · 2021Article
- Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.Cell death & disease · 2021Article
- Plasticity of Paneth cells and their ability to regulate intestinal stem cells.Stem cell research & therapy · 2020Review
- Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice.Life science alliance · 2020Article
- DeMISTifying Paneth Cell Maturation.Cellular and molecular gastroenterology and hepatology · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPaneth cells are professional secretory cells found within the small intestinal crypt epithelium. Although their role as part of the innate immune complex providing antimicrobial secretory products is well-known, the mechanisms that control secretory capacity are not well-understood. MIST1 is a scaling factor that is thought to control secretory capacity of exocrine cells.
methodsMist1
resultsAbsence of MIST1 resulted in increased numbers of Paneth cells exhibiting an intermediate cell phenotype but otherwise did not alter overall epithelial cell lineage allocation. Muc2 and lysozyme staining confirmed the presence of intermediate cells at the crypt base of Mist1
conclusionsMIST1 plays an important role in organization of the Paneth cell secretory apparatus and managing endoplasmic reticulum stress. This role occurs downstream of Paneth cell lineage allocation.
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Registered trials
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