Evidence map›Paper›PMID 31330088›Full record

ArticleJournal of applied microbiology2019

Dose-dependant acute or subacute disease caused by Burkholderia pseudomallei strain NCTC 13392 in a BALB/c aerosol model of infection.

S G P Funnell, J A Tree, G J Hatch, S R Bate, G Hall, G Pearson, E L Rayner, A D G Roberts, J Vipond

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

S G P FunnellNational Infection Service, Public Health England (PHE), Salisbury, Wiltshire, UK.ORCID https://orcid.org/0000-0002-4254-2751
J A TreeNational Infection Service, Public Health England (PHE), Salisbury, Wiltshire, UK.ORCID https://orcid.org/0000-0002-1720-6764
G J HatchNational Infection Service, Public Health England (PHE), Salisbury, Wiltshire, UK.
S R BateNational Infection Service, Public Health England (PHE), Salisbury, Wiltshire, UK.
G HallNational Infection Service, Public Health England (PHE), Salisbury, Wiltshire, UK.
G PearsonNational Infection Service, Public Health England (PHE), Salisbury, Wiltshire, UK.
E L RaynerNational Infection Service, Public Health England (PHE), Salisbury, Wiltshire, UK.
A D G RobertsNational Infection Service, Public Health England (PHE), Salisbury, Wiltshire, UK.
J VipondNational Infection Service, Public Health England (PHE), Salisbury, Wiltshire, UK.
Public Health England · GB

Funding

National Institute of Allergy and Infectious Diseases N01-A1-30062NIAID NIH HHS N01 AI030062
6 · The paper itself

Abstract

aimsThe goal of this study was to examine, for the first time, the virulence and pathogenicity of aerosolized Burkholderia pseudomallei, strain NCTC 13392, in BALB/c mice in order to develop an animal model for testing novel medical countermeasures (MCMs) for the treatment of human acute and subacute (a disease state between acute and chronic) melioidosis. METHODS AND

resultsBALB/c mice were exposed to varying doses of aerosolized bacteria. Acute disease was seen in animals exposed to a very-high dose (≥10

conclusionsThis proof of concept study has shown that B. pseudomallei strain NCTC 13392 is virulent and pathogenic in BALB/c mice, when delivered by aerosol. By varying the doses of aerosolized bacteria it was possible to mimic characteristics of both human acute and subacute melioidosis, at the same time, within the same study. SIGNIFICANCE AND IMPACT OF THE STUDY: Burkholderia pseudomallei, the aetiological agent of melioidosis, causes a serious and often fatal disease in humans and animals. Novel MCMs are urgently needed for both public health and biodefense purposes. The present model provides a useful tool for the assessment and evaluation of new MCMs (e.g. therapeutics and vaccines) and offers the potential for testing new treatments for both subacute to chronic and acute melioidosis prior to human clinical trials.

Indexed as

Burkholderia pseudomalleiDisease Models, AnimalMelioidosisAerosolsAnimalsMiceMice, Inbred BALB CAerosolsaerosolBALB/cBurkholderiadoseMelioidosispseudomalleisubacute

Identifiers

PMID31330088
PMCPMC6747009
OpenAlexW2963340298

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.