ArticleCerebral cortex (New York, N.Y. : 1991)2020
The Graded Change in Connectivity across the Ventromedial Prefrontal Cortex Reveals Distinct Subregions.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Cortical Gradients Support Mental Time Travel into the Past and Future: Evidence from Activation Likelihood Estimation Meta-analysis.Neuropsychology review · 2026Pooled it
- Multiple dimensions underlying the functional organization of the language network.NeuroImage · 2021Pooled it
- A multi-modal parcellation of human globus pallidus and its implications for symptom prediction and stratification in Parkinson's disease.BMC medicine · 2026Article
- Ventromedial prefrontal cortex attenuates the link between physiological heart rate reactions to unfairness and value computations in normative decision making.Social cognitive and affective neuroscience · 2026Article
- From single scenes to extended scenarios: The role of the ventromedial prefrontal cortex in the construction of imagery-rich events.PloS one · 2026Article
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- Emergence of Categorical Representations in Parietal and Ventromedial Prefrontal Cortex across Extended Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Structure-function coupling in highly sampled individual brains.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Impact of brain parcellation on prediction performance in models of cognition and demographics.Human brain mapping · 2024Article
- Graded functional organization in the left inferior frontal gyrus: evidence from task-free and task-based functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Distinct but cooperating brain networks supporting semantic cognition.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Bipartite functional fractionation within the neural system for social cognition supports the psychological continuity of self versus other.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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- A tale of two gradients: differences between the left and right hemispheres predict semantic cognition.Brain structure & function · 2022Article
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- Article
- A gradient from long-term memory to novel cognition: Transitions through default mode and executive cortex.NeuroImage · 2020Article
- Functional differentiation in the human ventromedial frontal lobe: A data-driven parcellation.Human brain mapping · 2020Article
- Psychotherapy in pain management: New viewpoints and treatment targets based on a brain theory.AIMS neuroscience · 2020Article
- Left Inferior Frontal Gyrus Participates in Mediating the Renewal Effect Irrespective of Context Salience.Frontiers in behavioral neuroscience · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The functional heterogeneity of the ventromedial prefrontal cortex (vmPFC) suggests it may include distinct functional subregions. To date these have not been well elucidated. Regions with differentiable connectivity (and as a result likely dissociable functions) may be identified using emergent data-driven approaches. However, prior parcellations of the vmPFC have only considered hard splits between distinct regions, although both hard and graded connectivity changes may exist. Here we determine the full pattern of change in structural and functional connectivity across the vmPFC for the first time and extract core distinct regions. Both structural and functional connectivity varied along a dorsomedial to ventrolateral axis from relatively dorsal medial wall regions to relatively lateral basal orbitofrontal cortex. The pattern of connectivity shifted from default mode network to sensorimotor and multimodal semantic connections. This finding extends the classical distinction between primate medial and orbital regions by demonstrating a similar gradient in humans for the first time. Additionally, core distinct regions in the medial wall and orbitofrontal cortex were identified that may show greater correspondence to functional differences than prior hard parcellations. The possible functional roles of the orbitofrontal cortex and medial wall are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.