Observational studyPloS one2019
Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward.
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between age and medication-related hospital admission in adults: a systematic review and meta-analysis.International journal of clinical pharmacy · 2026Pooled it
- Effect of integrated medicines management on quality of discharge medication information-a secondary endpoint in a randomized controlled trial.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2024Trial
- Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) - a randomized controlled trial.BMC health services research · 2022Trial
- Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial.BMJ open · 2020Trial
- Evaluating challenges care-partners and older adults confront after major elective surgery: A multimethods study.Surgery · 2026Article
- Polypharmacy in Older Adults: A Narrative Review of Clinical Risks, Deprescribing Strategies, and Interdisciplinary Management.Geriatrics (Basel, Switzerland) · 2026Review
- Acute mesenteric ischemia in older adults: clinical profiles, management patterns, and outcomes in medical and surgical settings.European geriatric medicine · 2026Observational
- Article
- Impact of electronic prescribing on medication changes in users of multidose drug dispensing.Exploratory research in clinical and social pharmacy · 2025Article
- Drug-related emergency department visits: external validation of an assessment tool in a general emergency department population.International journal of clinical pharmacy · 2024Article
- The impact of mental state altering medications on preventable falls after total hip or total knee arthroplasty: a systematic review and meta-analysis.Patient safety in surgery · 2024Review
- Medication-Related Hospital Admission Among Patients Admitted to the Emergency Ward at the University of Gondar, North West Ethiopia: A Cross Sectional Study.Drug, healthcare and patient safety · 2024Article
- Drug-related problems identified by clinical pharmacists in an academic medical centre in Thailand.Journal of pharmaceutical policy and practice · 2024Article
- A coordinated approach for managing polypharmacy among children with medical complexity: rationale and design of the Pediatric Medication Therapy Management (pMTM) randomized controlled trial.BMC health services research · 2023Article
- Additional value of a triggerlist as selection criterion in identifying patients at high risk of medication-related hospital admission: a retrospective cohort study.International journal of clinical pharmacy · 2022Article
- Observational
- Potential drug-drug interactions in drug therapy for older adults with chronic coronary syndrome at hospital discharge: A real-world study.Frontiers in pharmacology · 2022Article
- Drug-Related Hospital Admissions and Associated Factors among Adults Admitted to Felege Hiwot Comprehensive and Specialized Hospital, North West Ethiopia.Journal of environmental and public health · 2022Article
- Self-administration of medications for chronic diseases and drug-related hospital admissions in elderly patients at a Thai hospital.International journal of clinical pharmacy · 2021Article
- Transforming a Patient Registry Into a Customized Data Set for the Advanced Statistical Analysis of Health Risk Factors and for Medication-Related Hospitalization Research: Retrospective Hospital Patient Registry Study.JMIR medical informatics · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnowledge of risk factors for drug-related hospitalizations (DRHs) is limited.
aimTo examine the prevalence of DRHs and the relationships between DRHs and various variables in multimorbid patients admitted to an internal medicine ward.
methodsMultimorbid patients ≥ 18 years, using minimum of four regular drugs from minimum two therapeutic classes, were included from the Internal Medicine ward, Oslo University Hospital, Norway, from August 2014 to March 2016. Clinical pharmacists prospectively conducted medicines reconciliations and reviews to reveal drug-related problems (DRPs). Blinded for identified DRPs, an interdisciplinary group retrospectively made comprehensive, clinical assessments of each patient case to classify hospitalizations as drug-related (DRH) or non-drug-related (non-DRH). Age, sex distribution, Charlson Comorbidity Index (CCI), renal function, aberrant genotype frequencies, body-mass index, number of drugs, proportion of patients which received assistance for drug administration from the home care service, and/or through multidose-dispensed drugs, and occurrence of specific DRP subgroups, were compared separately between patients with DRHs versus non-DRHs, followed by multiple logistic regression analysis.
resultsHospitalizations were classified as drug-related in 155 of the 404 included patients (38%). Factors significantly associated with DRHs were occurrence of adverse effect DRPs (adjusted odds ratio (OR) 3.3, 95% confidence interval (CI) 1.4-8.0), adherence issues (OR 2.9, 1.1-7.2), home care (OR 1.9, 1.1-3.5), drug monitoring DRPs (OR 1.9, 1.2-3.0), and CCI score ≥6 (OR 0.33, 0.14-0.77). Frequencies of aberrant genotypes did not differ between the patient groups, but in 41 patients with DRHs (26.5%), gene-drug interactions influenced the assessments of DRHs.
conclusionDRHs are prevalent in multimorbid patients with adverse effect DRPs and adherence issues as the most important risk factors.
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