Observational studyPLoS neglected tropical diseases2019
Ultrasound-guided minimally invasive autopsy as a tool for rapid post-mortem diagnosis in the 2018 Sao Paulo yellow fever epidemic: Correlation with conventional autopsy.
Observational study in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- A systematic review of ultrasound to predict severe disease in patients with dengue and other viral infections associated with hemorrhagic fevers.PLoS neglected tropical diseases · 2026Pooled it
- Autopsy practices for high-consequence infectious diseases: global guidelines, alternatives, and the BSL-4 gap.Emerging microbes & infections · 2026Review
- Pulmonary Complications in Fatal Yellow Fever, Brazil, 2017-2019.Emerging infectious diseases · 2026Article
- Knowledge, acceptability, and attitudes regarding minimally invasive tissue sampling (MITS) techniques in Brazil.PLOS global public health · 2026Article
- Accelerating Proficiency in Minimally Invasive Autopsy for Infectious Disease Diagnosis and Research: A Strategic Framework.Revista da Sociedade Brasileira de Medicina Tropical · 2026Observational
- Postmortem Abdominal Ultrasound in Healthy Wild Mammals for Application in Forensic Veterinary Medicine.Veterinary medicine international · 2026Article
- The current state of forensic imaging - recommended radiological tools and international guidelines.International journal of legal medicine · 2025Review
- Percutaneous core needle biopsy guided by ultrasound: a narrative review.Journal of ultrasound · 2025Review
- Type I Interferons in SARS-CoV-2 Cutaneous Infection: Is There a Role in Antiviral Defense?International journal of molecular sciences · 2025Article
- Nipah virus infection: preparedness for the pathological diagnosis of an emerging Paramyxoviridae disease with epidemic potential.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Concordance between MITS and conventional autopsies for pathological and virological diagnoses.International journal of legal medicine · 2024Article
- Accuracy of the Verbal Autopsy questionnaire in the diagnosis of COVID-19 deaths in a Brazilian capital.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Neuropathology of yellow fever autopsy cases.Tropical diseases, travel medicine and vaccines · 2023Article
- What else in times of COVID-19? The role of minimally invasive autopsy for the differential diagnosis of acute respiratory failure in a case of kala-azar.Revista do Instituto de Medicina Tropical de Sao Paulo · 2023Article
- Phylogeographic patterns of the yellow fever virus around the metropolitan region of São Paulo, Brazil, 2016-2019.PLoS neglected tropical diseases · 2022Article
- Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology.Critical care (London, England) · 2022Article
- Post-Mortem Diagnosis of Pediatric Dengue Using Minimally Invasive Autopsy during the COVID-19 Pandemic in Brazil.Tropical medicine and infectious disease · 2022Article
- Risk Factors for Acute Kidney Injury and Death in Patients Infected With the Yellow Fever Virus During the 2018 Outbreak in São Paulo, Brazil.Kidney international reports · 2022Article
- Observational
- Ultrasound-Guided Minimally Invasive Tissue Sampling: A Minimally Invasive Autopsy Strategy During the COVID-19 Pandemic in Brazil, 2020.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNew strategies for collecting post-mortem tissue are necessary, particularly in areas with emerging infections. Minimally invasive autopsy (MIA) has been proposed as an alternative to conventional autopsy (CA), with promising results. Previous studies using MIA addressed the cause of death in adults and children in developing countries. However, none of these studies was conducted in areas with an undergoing infectious disease epidemic. We have recently experienced an epidemic of yellow fever (YF) in Brazil. Aiming to provide new information on low-cost post-mortem techniques that could be applied in regions at risk for infectious outbreaks, we tested the efficacy of ultrasound-guided MIA (MIA-US) in the diagnosis of patients who died during the epidemic. METHODOLOGY/PRINCIPAL
findingsIn this observational study, we performed MIA-US in 20 patients with suspected or confirmed YF and compared the results with those obtained in subsequent CAs. Ultrasound-guided biopsies were used for tissue sampling of liver, kidneys, lungs, spleen, and heart. Liver samples from MIA-US and CA were submitted for RT-PCR and immunohistochemistry for detection of YF virus antigen. Of the 20 patients, 17 had YF diagnosis confirmed after autopsy by histopathological and molecular analysis. There was 100% agreement between MIA-US and CA in determining the cause of death (panlobular hepatitis with hepatic failure) and main disease (yellow fever). Further, MIA-US obtained samples with good quality for molecular studies and for the assessment of the systemic involvement of the disease. Main extrahepatic findings were pulmonary hemorrhage, pneumonia, acute tubular necrosis, and glomerulonephritis. One patient was a 24-year-old, 27-week pregnant woman; MIA-US assessed the placenta and provided adequate placental tissue for analysis.
conclusionsMIA-US is a reliable tool for rapid post-mortem diagnosis of yellow fever and can be used as an alternative to conventional autopsy in regions at risk for hemorrhagic fever outbreaks with limited resources to perform complete diagnostic autopsy.
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