Evidence map›Paper›PMID 31329308›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2020

Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy.

Mohammad R Khan, Roger K Smith, Frederic David, Richard Lam, Gillian Hughes, Roberta De Godoy, Andrew J Carr, Allen E Goodship, Jayesh Dudhia

Abstract readEvaluation Study
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  3. Article
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  8. Large animal models for the study of tendinopathy.Frontiers in cell and developmental biology · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammad R KhanClinical Sciences and Services, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom.ORCID 0000-0002-3728-011X
Roger K SmithClinical Sciences and Services, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom.
Frederic DavidClinical Sciences and Services, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom.
Richard LamClinical Sciences and Services, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom.ORCID 0000-0001-7738-8312
Gillian HughesClinical Sciences and Services, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom.
Roberta De GodoyWrittle Agricultural College, Lordship Road, Chelmsford, Essex, CM1 3RR, United Kingdom.ORCID 0000-0003-0037-5286
Andrew J CarrBotnar Research Centre, Institute of Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, United Kingdom.ORCID 0000-0001-5940-1464
Allen E GoodshipUCL Institute of Orthopaedics and Musculoskeletal Science (IOMS), Stanmore, HA7 4LP, United Kingdom.ORCID 0000-0003-1859-9130
Jayesh DudhiaClinical Sciences and Services, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom.ORCID 0000-0002-2503-697X

Funding

Department of Health II-LB-0715-20001Medical Research Council MR/J006815/1Medical Research Council MR/R015651/1Medical Research Council, United Kingdom MRJ0068151
6 · The paper itself

Abstract

Intra-synovial tendon injuries are a common orthopedic problem with limited treatment options. The synovium is a specialized connective tissue forming the inner encapsulating lining of diarthrodial joints and intra-synovial tendons. It contains multipotent mesenchymal stromal cells that render it a viable source of progenitors for tendon repair. This study evaluated the effects of autologous implantation of cells derived from normal synovium (synovial membrane cells [SMCs]) in augmenting repair in an ovine model of intra-synovial tendon injury. For this purpose, synovial biopsies were taken from the right digital flexor tendon sheath following creation of a defect to the lateral deep digital flexor tendon. Mononuclear cells were isolated by partial enzymatic digestion and assessed for MSC characteristics. Cell tracking and tendon repair were assessed by implanting 5 × 10

Indexed as

AnimalsCell DifferentiationCell LineageCells, CulturedDisease Models, AnimalFemaleFlow CytometryMagnetic Resonance ImagingMultipotent Stem CellsSheepSynovial MembraneTendon InjuriesTendonsdigital flexor tendonovinesynovial multipotent cellssynoviumtendon

Identifiers

PMID31329308
PMCPMC6973225

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.