ArticleEpilepsia2019
Increased gamma and decreased fast ripple connections of epileptic tissue: A high-frequency directed network approach.
Article in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pooled it
- Ictal Epileptogenic Network Differences in Posterior Cingulate Epilepsy Subtypes Based on SEEG.CNS neuroscience & therapeutics · 2026Article
- Article
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Seizure Type Classification Based on Hybrid Feature Engineering and Mutual Information Analysis Using Electroencephalogram.Entropy (Basel, Switzerland) · 2025Article
- Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain.Brain structure & function · 2025Article
- Spike ripples localize the epileptogenic zone best: an international intracranial study.Brain : a journal of neurology · 2024Article
- Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024Review
- Interictal MEG abnormalities to guide intracranial electrode implantation and predict surgical outcome.ArXiv · 2023Article
- Epileptic Tissue Localization through Skewness-Based Functional Connectivity in the High-Frequency Band of Intracranial EEG.Bioengineering (Basel, Switzerland) · 2023Article
- Interictal magnetoencephalography abnormalities to guide intracranial electrode implantation and predict surgical outcome.Brain communications · 2023Article
- [Localization of epileptogenic zone based on reconstruction of dynamical epileptic network and virtual resection].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- High-Frequency Oscillations and Epileptogenic Network.Current neuropharmacology · 2022Article
- Drug-resistant epilepsy and the hypothesis of intrinsic severity: What about the high-frequency oscillations?Epilepsia open · 2022Review
- Normative intracranial EEG maps epileptogenic tissues in focal epilepsy.Brain : a journal of neurology · 2022Article
- Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study.Frontiers in neurology · 2022Article
- Localizing the Epileptogenic Zone with Novel Biomarkers.Seminars in pediatric neurology · 2021Review
- Interictal high frequency background activity as a biomarker of epileptogenic tissue.Brain communications · 2021Article
- Presurgical Evaluation of Epilepsy Using Resting-State MEG Functional Connectivity.Frontiers in human neuroscience · 2021Review
- Active probing to highlight approaching transitions to ictal states in coupled neural mass models.PLoS computational biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveNew insights into high-frequency electroencephalographic activity and network analysis provide potential tools to improve delineation of epileptic tissue and increase the chance of postoperative seizure freedom. Based on our observation of high-frequency oscillations "spreading outward" from the epileptic source, we hypothesize that measures of directed connectivity in the high-frequency range distinguish epileptic from healthy brain tissue.
methodsWe retrospectively selected refractory epilepsy patients with a malformation of cortical development or tumor World Health Organization grade I/II who underwent epilepsy surgery with intraoperative electrocorticography for tailoring the resection based on spikes. We assessed directed functional connectivity in the theta (4-8 Hz), gamma (30-80 Hz), ripple (80-250 Hz), and fast ripple (FR; 250-500 Hz) bands using the short-time direct directed transfer function, and calculated the total, incoming, and outgoing propagation strength for each electrode. We compared network measures of electrodes covering the resected and nonresected areas separately for patients with good and poor outcome, and of electrodes with and without spikes, ripples, and FRs (group level: paired t test; patient level: Mann-Whitney U test). We selected the measure that could best identify the resected area and channels with epileptic events using the area under the receiver operating characteristic curve, and calculated the positive and negative predictive value, sensitivity, and specificity.
resultsWe found higher total and outstrength in the ripple and gamma bands in resected tissue in patients with good outcome (ripple SIGNIFICANCE: Interictally, epileptic tissue is isolated in the FR band and acts as a driver up to the (fast) ripple frequency range. The gamma band total strength seems promising to delineate epileptic tissue intraoperatively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.