ArticleJournal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
Neural Response to Rewards, Stress and Sleep Interact to Prospectively Predict Depressive Symptoms in Adolescent Girls.
Article in Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- The effects of stress on reward responsiveness: a systematic review and preliminary meta-analysis of the event-related potential literature.Cognitive, affective & behavioral neuroscience · 2024Pooled it
- Great Expectations: A Critical Review of and Suggestions for the Study of Reward Processing as a Cause and Predictor of Depression.Biological psychiatry · 2021Pooled it
- Efficacy ofWorld journal of psychiatry · 2025Trial
- Negative interpretation bias and repetitive negative thinking as mechanisms in the association between insomnia and depression in young adults.The British journal of clinical psychology · 2026Article
- Low reward responsiveness as a moderator of chronic stress effects on depressive symptoms in adolescents: An examination of monetary and social rewards.Journal of affective disorders · 2026Article
- Insomnia longitudinally predicts reduced reward motivation in adults with elevated depressive symptoms.Journal of affective disorders · 2026Article
- The interplay of reward responsiveness and socioeconomic disadvantage in the prospective prediction of depression symptoms in youth.Psychological medicine · 2025Article
- An Integrated Immuno-Reward Model of Adolescent Depression: Theory, Evidence, and Implications.Current directions in psychological science · 2025Article
- Adverse childhood experiences and internalizing symptoms: the moderating role of neural responses to threat.Neurobiology of stress · 2025Article
- Childhood anhedonia symptoms and stressful life events predict the development of reward-related brain activity across adolescence.Development and psychopathology · 2025Article
- Anhedonia Links Sleep Problems and Suicidal Thoughts: An Intensive Longitudinal Study in High-Risk Adolescents.Research on child and adolescent psychopathology · 2025Article
- Adolescent predictors of substance use in young adulthood among individuals with childhood-onset chronic pain: A follow-up study.European journal of pain (London, England) · 2025Observational
- Reward-Related Brain Activity Mediates the Relationship Between Decision-Making Deficits and Pediatric Depression Symptom Severity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Attenuated Doors-Locked P300 Amplitude and Elevated Depressive Symptoms: Effects of Age and Sex in Two Independent Samples of Youth.Psychophysiology · 2025Article
- [Research advances in reward positivity and internalizing and externalizing problems in children and adolescents].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- A biopsychosocial approach to sleep health during puberty: Individual and contextual aspects and the role of gender differences. A narrative review.Cogent mental health · 2025Review
- Association between sleep disorder and anhedonia in adolescence with major depressive disorder: the mediating effect of stress.BMC psychiatry · 2024Article
- Reduced reward responsiveness and depression vulnerability: Consideration of social contexts and implications for intervention.Psychophysiology · 2024Review
- Behavioral and psychiatric correlates of brain responses to social feedback.Psychophysiology · 2024Article
- Adolescents' Sexual Orientation and Behavioral and Neural Reactivity to Peer Acceptance and Rejection: The Moderating Role of Family Support.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Blunted reward processing both characterizes major depressive disorder and predicts increases in depressive symptoms. However, little is known about the interaction between blunted reward processing and other risk factors in relation to increases in depressive symptoms. Stressful life events and sleep problems are prominent risk factors that contribute to the etiopathogenesis of depression and have been linked to reward dysfunction; these factors may interact with reward dysfunction to predict increased depressive symptoms. In a large sample of 8- to 14-year-old adolescent girls, the current study examined how blunted reward processing, stressful life events, and sleep problems at baseline interacted to predict increases in depressive symptoms 1 year later. Reward processing was indexed by the reward positivity (RewP), an event-related potential elicited during a simple monetary reward paradigm (i.e., Doors task). Two-way interactions confirmed that a blunted RewP predicted increased depressive symptoms at (a) high levels of stress but not average or low levels of stress, and (b) high and average levels of sleep problems but not low levels of sleep problems. Finally, a 3-way interaction confirmed that a blunted RewP predicted increased depressive symptoms at high levels of stress and sleep problems but not average or low levels of stress and sleep problems. Thus, adolescents characterized by low reward response (i.e., blunted RewP) were at an increased risk of developing depressive symptoms if they experienced increased stressful life events or sleep problems; moreover, risk was greatest among adolescents characterized by all 3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.