Evidence map›Paper›PMID 31328895›Full record

ArticleObesity (Silver Spring, Md.)2019

Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance.

Kelsey Gabel, Cynthia M Kroeger, John F Trepanowski, Kristin K Hoddy, Sofia Cienfuegos, Faiza Kalam, Krista A Varady

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 11 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 11 syntheses or guidelines pooled it, 143 citations in OpenAlex.

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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Kelsey GabelDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Cynthia M KroegerDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
John F TrepanowskiDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Kristin K HoddyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Sofia CienfuegosDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Faiza KalamDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Krista A VaradyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0002-9279-9934
University of Illinois Chicago · USThe University of Sydney · AU

Funding

Alternate day fasting for weight loss, weight maintenance, and cardio-protectionR01HL106228 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VARADY, KRISTA AMY · 2011 to 2014
$1.5M
NHLBI NIH HHS R01 HL106228NHLBI NIH HHS R01HL106228
6 · The paper itself

Abstract

objectiveThis study compared the effects of alternate-day fasting (ADF) with those of daily calorie restriction (CR) on body weight and glucoregulatory factors in adults with overweight or obesity and insulin resistance.

methodsThis secondary analysis examined the data of insulin-resistant individuals (n = 43) who participated in a 12-month study that compared ADF (25% energy needs on "fast days"; 125% energy needs on alternating "feast days") with CR (75% energy needs every day) and a control group regimen.

resultsIn insulin-resistant participants, weight loss was not different between ADF (-8% ± 2%) and CR (-6% ± 1%) by month 12, relative to controls (P < 0.0001). Fat mass and BMI decreased (P < 0.05) similarly from ADF and CR. ADF produced greater decreases (P < 0.05) in fasting insulin (-52% ± 9%) and insulin resistance (-53% ± 9%) compared with CR (-14% ± 9%; -17% ± 11%) and the control regimen by month 12. Lean mass, visceral fat mass, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, blood pressure, C-reactive protein, tumor necrosis factor α, and interleukin 6 values remained unchanged.

conclusionsThese findings suggest that ADF may produce greater reductions in fasting insulin and insulin resistance compared with CR in insulin-resistant participants despite similar decreases in body weight.

Indexed as

AdolescentAdultAgedCaloric RestrictionFastingFemaleHumansInsulinInsulin ResistanceMaleMiddle AgedYoung AdultInsulin

Identifiers

PMID31328895
PMCPMC7138754
OpenAlexW2964075095

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.