ArticleJournal of clinical laboratory analysis2019
Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Appraising circular RNAs as novel biomarkers for the diagnosis and prognosis of gastric cancer: A pair-wise meta-analysis.Journal of clinical laboratory analysis · 2020Pooled it
- Clinical Significance of Disulfidptosis-related Genes and Functional Analysis in Gastric Cancer.Journal of Cancer · 2024Article
- Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs.Journal of periodontal research · 2022Article
- The expression profile and clinical application value of hsa_circ_0016148 in head and neck squamous cell carcinoma.Journal of clinical laboratory analysis · 2021Article
- The role of circRNA derived from RUNX2 in the serum of osteoarthritis and its clinical value.Journal of clinical laboratory analysis · 2021Article
- Low expression of hsa_circ_0001811 in gastric cancer and its role in clinical diagnosis.Journal of clinical laboratory analysis · 2021Article
- CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- CircAP2A2 acts as a ceRNA to participate in infantile hemangiomas progression by sponging miR-382-5p via regulating the expression of VEGFA.Journal of clinical laboratory analysis · 2020Article
- The function and mechanism of circular RNAs in gastrointestinal tumours.Cell proliferation · 2020Review
- Identification of the Combinatorial Effect of miRNA Family Regulatory Network in Different Growth Patterns of GC.Molecular therapy oncolytics · 2020Article
- Circular RNA circMAN2B2 promotes growth and migration of gastric cancer cells by down-regulation of miR-145.Journal of clinical laboratory analysis · 2020Article
- Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR-20a.Journal of clinical laboratory analysis · 2020Article
- Gastric juice piR-1245: A promising prognostic biomarker for gastric cancer.Journal of clinical laboratory analysis · 2020Article
- Circular RNAs in Gastric Cancer: Potential Biomarkers and Therapeutic Targets.BioMed research international · 2020Review
- Circular RNAs and gastrointestinal cancers: Epigenetic regulators with a prognostic and therapeutic role.Critical reviews in oncology/hematology · 2020Review
- Circular RNA circNRIP1 Sponges microRNA-138-5p to Maintain Hypoxia-Induced Resistance to 5-Fluorouracil Through HIF-1α-Dependent Glucose Metabolism in Gastric Carcinoma.Cancer management and research · 2020Article
- Clinical Significance of Has_circ_0060937 in Bone Metastasis of NSCLC.International journal of general medicine · 2020Article
- Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues.Journal of clinical laboratory analysis · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCircular RNAs (circRNAs) are a special class of endogenous noncoding RNAs that have numerous biological functions in normal situation and diseases including cancers. However, the clinical significance of circRNAs in gastric cancer (GC) remains largely unknown. Here, we chose two representative circRNAs, hsa_circ_0067582 and hsa_circ_0005758, to investigate their clinical significance in GC patients.
methodsUsing real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR), we explored the expression levels of hsa_circ_0067582 and hsa_circ_0005758 in tissues with different stages of gastric tumorigenesis. Then, the relationships between their expression levels and GC patients' clinicopathological factors were further investigated. Receiver operating characteristic (ROC) curves were established for evaluating diagnostic values of hsa_circ_0067582 and hsa_circ_0005758.
resultsCompared with healthy control tissues, both hsa_circ_0067582 and hsa_circ_0005758 were significantly decreased in GC tissues. Besides, hsa_circ_0067582 expression was associated with GC patients' tissue CEA level (P <.001) and stages (P = .037); and hsa_circ_0005758 expression was relevant to tissue CEA level (P < .001) and perineural invasion (P = .048). The area under the ROC curve (AUC) of hsa_circ_0067582 was up to 0.671. The cutoff value was set at 10.61, with which the sensitivity and specificity were 55.2% and 75.0%, respectively. Similar to hsa_circ_0005758, the AUC of hsa_circ_0005758 was 0.721. The cutoff value was set at 10.20, with which the sensitivity and specificity were 75.0% and 67.7%, respectively.
conclusionThese results showed that both hsa_circ_0067582 and hsa_circ_0005758 may play an important role in gastric carcinogenesis; and they may be potential indicators for GC diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.