ArticleThe EMBO journal2019
Going for the Golgi: small PDI protein helps ATF6 perform better under stress.
Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- The mechanism and clinical research of vagus nerve electrical stimulation in the treatment of myocardial ischemia-reperfusion injury.iScience · 2026Review
- Endoplasmic Reticulum Stress in Cancer Progression: A Comprehensive Review of Its Role and Mechanisms.International journal of medical sciences · 2025Review
- Article
- Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for Intervertebral Disc Degeneration.Frontiers in cell and developmental biology · 2021Review
- Unfolded Protein Response in Lung Health and Disease.Frontiers in medicine · 2020Article
- Going for the Golgi: small PDI protein helps ATF6 perform better under stress.The EMBO journal · 2019Article
- How important are fatty acids in human health and can they be used in treating diseases?Gut microbesReview
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATF6 is a major signal transducer for cellular reprogramming in response to protein mis-folding in the endoplasmic reticulum. However, the mechanism by which ATF6 senses unfolded proteins and becomes activated is not yet known. In this issue of The EMBO Journal, Oka et al show that ERp18, a single-domain member of the protein disulfide isomerase family, interacts preferentially with ATF6 under stress conditions and regulates ATF6 transport to the Golgi apparatus. Furthermore, ERp18 impacts the ATF6 cleavage product generated in the Golgi, ultimately determining whether or not ATF6 becomes a functional transcription factor and induces the unfolded protein response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.