Evidence map›Paper›PMID 31328702›Full record

SynthesisInternational journal of technology assessment in health care2019

Cost-Effectiveness Evaluations of Psychological Therapies for Schizophrenia and Bipolar Disorder: A Systematic Review.

Gemma Elizabeth Shields, Deborah Buck, Jamie Elvidge, Karen Petra Hayhurst, Linda Mary Davies

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of technology assessment in health care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 5 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Cognitive behavioral therapy for psychosis: a cost-effectiveness study using the EPiSODe model.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gemma Elizabeth ShieldsCentre for Health Economics, Division of Population Health, University of Manchester.ORCID https://orcid.org/0000-0003-4869-7524
Deborah BuckPersonal and Social Services Research Unit, University of Manchester.
Jamie ElvidgeNational Institute for Health and Care Excellence, United Kingdom.
Karen Petra HayhurstDivision of Psychology and Mental Health, University of Manchester, Manchester.
Linda Mary DaviesCentre for Health Economics, Division of Population Health, University of Manchester.
University of Manchester · GBNational Institute for Health and Care Excellence · GB

Funding

Department of Health RP-PG-0611-20004
6 · The paper itself

Abstract

objectivesThis review aims to assess the cost-effectiveness of psychological interventions for schizophrenia/bipolar disorder (BD), to determine the robustness of current evidence and identify gaps in the available evidence.

methodsElectronic searches (PsycINFO, MEDLINE, Embase) identified economic evaluations relating incremental cost to outcomes in the form of an incremental cost-effectiveness ratio published in English since 2000. Searches were concluded in November 2018. Inclusion criteria were: adults with schizophrenia/BD; any psychological/psychosocial intervention (e.g., psychological therapy and integrated/collaborative care); probability of cost-effectiveness at explicitly defined thresholds reported. Comparators could be routine practice, no intervention, or alternative psychological therapies. Screening, data extraction, and critical appraisal were performed using pre-specified criteria and forms. Results were summarized qualitatively. The protocol was registered on the PROSPERO database (CRD42017056579).

resultsOf 3,864 studies identified, 12 met the criteria for data extraction. All were integrated clinical and economic randomized controlled trials. The most common intervention was cognitive behavioral therapy (CBT, 6/12 studies). The most common measure of health benefit was the quality-adjusted life-year (6/12). Follow-up ranged from 6 months to 5 years. Interventions were found to be cost-effective in most studies (9/12): the probability of cost-effectiveness ranged from 35-99.5 percent. All studies had limitations and demonstrated uncertainty (particularly related to incremental costs).

conclusionsMost studies concluded psychological interventions for schizophrenia/BD are cost-effective, including CBT, although there was notable uncertainty. Heterogeneity across studies makes it difficult to reach strong conclusions. There is a particular need for more evidence in the population with BD and for longer-term evidence across both populations.

Indexed as

Bipolar DisorderCognitive Behavioral TherapyCost-Benefit AnalysisHealth ExpendituresHealth ResourcesHealth ServicesHumansQuality-Adjusted Life YearsRandomized Controlled Trials as TopicSchizophreniaBipolar disorderCost-effectivenessCost-utilityEconomic evaluationSchizophrenia

Identifiers

PMID31328702
PMCPMC6707812
OpenAlexW2963941373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.