Observational studyJournal of gynecologic oncology2019
Improved preoperative risk stratification with CA-125 in low-grade endometrial cancer: a multicenter prospective cohort study.
Observational study in Journal of gynecologic oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- A nomogram based on immunohistochemistry and lymphocyte-to-monocyte ratio for predicting risk stratification in endometrial carcinoma.Oncology letters · 2026Article
- Article
- Review
- Preoperative cancer antigen-125 levels as a predictor of recurrence in early-stage endometrial cancer.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels.Frontiers in oncology · 2024Article
- Clinical Applicability of Tissue Polypeptide Antigen and CA-125 in Gynecological Malignancies.Biomedicines · 2023Article
- The relationship between serum CA-125 level and recurrence in surgical stage I endometrial cancer patients.Journal of the Chinese Medical Association : JCMA · 2023Article
- Preoperative Prognostic Nutritional Index Is a Prognostic Indicator of Cancer-Specific Survival in Patients Undergoing Endometrial Cancer Surgery.Journal of Korean medical science · 2023Article
- Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer.Cancers · 2023Article
- The Diagnostic Role of FGF 21 in Endometrial Cancer and Other Pathologies of the Uterine Corpus.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Peripheral Blood Lymphocyte Subsets as a Risk Predictor of Patients with Endometrioid Endometrial Cancer.Journal of inflammation research · 2022Article
- Estrogen-Induced Extracellular Calcium Influx Promotes Endometrial Cancer Progress by Regulating Lysosomal Activity and Mitochondrial ROS.Frontiers in medicine · 2022Article
- Current and Emerging Prognostic Biomarkers in Endometrial Cancer.Frontiers in oncology · 2022Review
- Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer.Healthcare (Basel, Switzerland) · 2021Article
- The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer.Journal of clinical medicine · 2021Article
- What is the predictive value of preoperative CA 125 level on the survival rate of type 1 endometrial cancer?Turkish journal of medical sciences · 2021Article
- Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinoma.Scientific reports · 2021Article
- Combination IETA Ultrasonographic Characteristics Simple Scoring Method With Tumor Biomarkers Effectively Improves the Differentiation Ability of Benign and Malignant Lesions in Endometrium and Uterine Cavity.Frontiers in oncology · 2021Article
- The Coefficient of Variation of Red Blood Cell Distribution Width Combined with Cancer Antigen 125 Predicts Postoperative Overall Survival in Endometrial Cancer.International journal of general medicine · 2021Article
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe global obesity epidemic has great impact on the prevalence of low-grade endometrial carcinoma. The preoperative tumor serum marker cancer antigen 125 (CA-125) might contribute to improved identification of high-risk patients within this group. The study aimed to investigate the prognostic value of CA-125 in relation to established preoperative prognosticators, with a focus on identifying patients with poor outcome in low-grade endometrial carcinoma (EC) patients.
methodsProspective multicenter cohort study including all consecutive patients surgically treated for endometrial carcinoma in nine collaborating hospitals from September 2011 until December 2013. All preoperative histopathological diagnoses were reviewed in a blinded manner. Associations between CA-125 and clinicopathological features were determined. Univariable and multivariable analysis by Cox regression were used. Separate analyses were performed for preoperatively designated low-grade and high-grade endometrial carcinoma patients.
resultsA total of 333 patients were analyzed. CA-125 was associated with poor prognostic features including advanced International Federation of Gynecology and Obstetrics (FIGO) stage. In multivariable analysis, age, preoperative tumor and CA-125 were significantly associated with disease-free survival (DFS); preoperative grade, tumor type, FIGO and CA-125 were significantly associated with disease-specific survival (DSS). Low-grade EC patients with elevated CA-125 revealed a DFS of 80.6% and DSS of 87.1%, compared to 92.1% and 97.2% in low-grade EC patients with normal CA-125.
conclusionPreoperative elevated CA-125 was associated with poor prognostic features and independently associated with DFS and DSS. Particularly patients with low-grade EC and elevated CA-125 represent a group with poor outcome and should be considered as high-risk endometrial carcinoma.
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