Evidence map›Paper›PMID 31328431›Full record

ArticleMolecular genetics & genomic medicine2019

Toll-like receptor 4 polymorphisms in Saudi population with cardiovascular diseases.

Abdelhabib Semlali, Mikhlid Al Mutairi, Ibrahim Oqla Alanazi, Hasan Awad Aljohi, Narasimha Reddy Parine, Abdullah Alhadheq, Abdulaziz A Al-Jafari, Abdulelah F Mobeirek, Abdullah Al Amri, Jilani P Shaik and 2 more

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Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Abdelhabib SemlaliGroupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Québec, QC, Canada.ORCID 0000-0002-5797-8304
Mikhlid Al MutairiZoology Department, College of Science King Saud University, Riyadh, Kingdom of Saudi Arabia.
Ibrahim Oqla AlanaziNational Center for Genomics Research (NCGR), King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Hasan Awad AljohiNational Center for Genomics Research (NCGR), King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Narasimha Reddy ParineGenome Research Chair, Department of Biochemistry, College of Science King Saud University, Riyadh, Kingdom of Saudi Arabia.
Abdullah AlhadheqZoology Department, College of Science King Saud University, Riyadh, Kingdom of Saudi Arabia.
Abdulaziz A Al-JafariDepartment of Biochemistry, Faculty of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Abdulelah F MobeirekCardiac Sciences Department, Faculty of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Abdullah Al AmriGenome Research Chair, Department of Biochemistry, College of Science King Saud University, Riyadh, Kingdom of Saudi Arabia.
Jilani P ShaikGenome Research Chair, Department of Biochemistry, College of Science King Saud University, Riyadh, Kingdom of Saudi Arabia.
Fatima-Zohra FilaliCentre Hospitalier Provincial (CHP) de Taounate, Taounate, Maroc.
Mohammad AlanaziGenome Research Chair, Department of Biochemistry, College of Science King Saud University, Riyadh, Kingdom of Saudi Arabia.
King Saud University · SAKing Abdulaziz City for Science and Technology · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundToll-like receptors play a substantial role in innate immunity and the effects of TLR4 genetic variants on cardiovascular diseases are still largely unknown. Therefore, we aimed to investigate the effects of TLR4 polymorphisms on cardiovascular diseases risk in the Saudi population.

methodsThree tag single-nucleotide polymorphisms (rs2770150, rs10759931, and rs4986790) in TLR4 were studied on 222 unrelated patients with cardiovascular diseases and 190 healthy volunteers.

resultsWe found that, in patients over 60 years old, the frequency of the TT genotype in rs2770150 and the variant allele G in rs10759931 were higher compared to the control group. Based on gender, the genotype frequency of rs2770150 increases the risk for cardiovascular diseases in female patients by 3.6-fold. The allele frequency for the G allele of rs10759931 increased the risk for CVDs in male patients by more than 1.5-fold. Furthermore, the genotype frequency of rs2770150 had a significant association with cardiovascular diseases in patients without hypertension and G allele of rs10759931 significantly increased the risk of cardiovascular diseases in patients that smoked. After Bonferroni correction only patients without hypertension showed significant risk of CVD with rs2770150.

conclusionA deeper understanding of the genetic variability of TLR4 will enable us to better identification of biomarkers for early detection and prognosis, and also enhance the decision-making process of treatments for cardiovascular diseases.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAgedAge FactorsAllelesBiomarkersCardiovascular DiseasesFemaleGenotypeHumansMaleMiddle AgedOdds RatioSaudi ArabiaToll-Like Receptor 4BiomarkersTLR4 protein, humanToll-Like Receptor 4cardiovascular diseaseinnate immune systemsingle-nucleotide polymorphismToll-Like Receptor 4

Identifiers

PMID31328431
PMCPMC7650605
OpenAlexW2963842139

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.