ArticleAging medicine (Milton (N.S.W))2018
Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort.
Article in Aging medicine (Milton (N.S.W)), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort.Aging medicine (Milton (N.S.W)) · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Serum pro-inflammatory markers may contribute to dementia pathophysiology and cognitive impairment. In a population-representative birth cohort, serum C-reactive protein (CRP), interleukin-6 (IL-6), and white cell count (WCC) were measured at age 60-64 years and cognition was assessed using the Addenbrooke's Cognitive Examination (ACE-III) at age 69 years. Higher baseline CRP and IL-6 were associated with lower ACE-III scores, but associations were attenuated on adjustment for educational attainment, sex, and other modifiable life course factors. No associations were found for CRP, IL-6, and WCC with visual search speed or verbal memory. In conclusion, the relationship between increased baseline systemic inflammation and poorer cognition in later life may be explained by, or share pathways with, education and other modifiable life course factors.
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Registered trials
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