ArticleGland surgery2019
BI-RADS 4 breast lesions: could multi-mode ultrasound be helpful for their diagnosis?
Article in Gland surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Statistically Rigorous and Interpretable Radiomics for Benign-Malignant Classification on the BUSI-WHU Breast Ultrasound Dataset.Journal of imaging informatics in medicine · 2026Article
- Exploring the Application of Contrast-Enhanced Ultrasound in ACR BI-RADS 4A Lesions (≤ 2 cm): A Prospective Multicenter Study in China.The breast journal · 2026Article
- Breast tumor diagnosis via multimodal deep learning using ultrasound B-mode and Nakagami images.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Innovative integration of automated breast volume scan and ultrasound elastography for enhanced differentiation of benign and malignant breast lesions.Scientific reports · 2025Article
- Novel study on the prediction of BI-RADS 4A positive lesions in mammography using deep learning technology and clinical factors.Quantitative imaging in medicine and surgery · 2024Article
- The Efficacy of MRI-Based ADC Measurements in Detecting Axillary Lymph Node Metastasis: Evaluation of a Prospective Study.Current oncology (Toronto, Ont.) · 2024Article
- Current status and future perspectives of contrast-enhanced ultrasound diagnosis of breast lesions.Journal of medical ultrasonics (2001) · 2024Review
- Factors Associated with False Positive Breast Cancer Results in the Real-Time Sonoelastography Evaluation of Solid Breast Lesions.Medicina (Kaunas, Lithuania) · 2024Article
- The Accuracy of Breast Cancer Diagnostic Tools.Cureus · 2024Article
- Diagnostic value of contrast-enhanced ultrasound and shear-wave elastography for small breast nodules.PeerJ · 2024Article
- Diagnostic value of multimodal ultrasound for breast cancer and prediction of sentinel lymph node metastases.Frontiers in cell and developmental biology · 2024Article
- Article
- Can Short-term Follow-up with Ultrasound be Offered as an Acceptable Alternative to Immediate Biopsy or Surgery for Patients with First Ultrasound Diagnosis of BI-RADS 4A Lesions?World journal of surgery · 2023Article
- Value of an expanded range of lesions on contrast-enhanced ultrasound for the diagnosis of hypervascular breast masses.Gland surgery · 2023Article
- Article
- Development and validation of a nomogram for discriminating between benign and malignant breast masses by conventional ultrasound and dual-mode elastography: a multicenter study.Quantitative imaging in medicine and surgery · 2023Article
- A clinical-radiomics nomogram based on multimodal ultrasound for predicting the malignancy risk in solid hypoechoic breast lesions.Frontiers in oncology · 2023Article
- Shear-wave elastography combined with contrast-enhanced ultrasound algorithm for noninvasive characterization of focal liver lesions.La Radiologia medica · 2023Article
- Non-mass Breast Lesions: Could Multimodal Ultrasound Imaging Be Helpful for Their Diagnosis?Diagnostics (Basel, Switzerland) · 2022Article
- A comparative efficacy study of diagnostic digital breast tomosynthesis and digital mammography in BI-RADS 4 breast cancer diagnosis.European journal of radiology · 2022Article
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6 authors.
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Abstract
backgroundThe malignant probability of Breast Imaging Reporting and Data System (BI-RADS) 4 breast lesions is 3-94%, which is a very large span, and thus leads to a high rate of unnecessary biopsy. Therefore, the differential diagnosis of benign and malignant BI-RADS 4 breast lesions has become extremely important. Thus, in this paper, we investigated the diagnostic value of conventional ultrasonography (US), contrast-enhanced ultrasound (CEUS) and shear wave elastography (SWE) for BI-RADS 4 breast lesions, and tried to figure out a multi-mode ultrasonic method for them.
methodsFrom March 2016 to May 2017, 118 breast lesions that were categorized as BI-RADS 4 lesions by US were studied with CEUS and SWE. All the lesions were confirmed by pathology via surgery or vacuum-assisted biopsy. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of US, CEUS and SWE were analyzed. Then the diagnostic efficacies of US, CEUS, SWE and the combination of these modalities were compared. Logistic regression analysis was performed to identify the independent risk factors. A multi-mode method to evaluate BI-RADS 4 lesions based on the logistic regression was developed.
resultsOf the 118 BI-RADS 4 lesions, 74 lesions (62.7%) were benign and 44 lesions (37.3%) were malignant. The diagnostic sensitivity and specificity for US, US + CEUS, US + SWE, US + CEUS + SWE were 88.6% and 75.7%, 86.4% and 94.6%, 88.6% and 90.5%, 97.7% and 93.2%, respectively. The area under the ROC curve (AUC) of US + SWE + CEUS was significantly higher than that of US (P<0.0001), US + CEUS (P=0.020), but there was no significant difference between the AUC of US + SWE + CEUS and the AUC of US + SWE.
conclusionsUS + CEUS + SWE and US + SWE could significantly improve the diagnostic efficiency and accuracy of US in the diagnosis of BI-RADS 4 breast lesions.
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