ArticleCureus2019
A Case of Sudden Very Late Onset of Severe Clozapine-induced Agranulocytosis Following an Influenza Vaccine.
Article in Cureus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Vaccination and clozapine use: a systematic review and an analysis of the VAERS database.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Clozapine and COVID-19 Vaccination: Effects on blood levels and leukocytes. An observational cohort study.Acta psychiatrica Scandinavica · 2022Observational
- A case report: Clozapine-induced leukopenia and neutropenia after mRNA COVID-19 vaccination.Neuropsychopharmacology reports · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Agranulocytosis can be a life-threatening condition because of its high risk of serious infection. It is extremely rare, with an incidence of one to five cases per million in the population per year. About 70% of the cases are associated with medications. Clozapine-induced leukopenia is a well-known clinical entity, justifying regular hematologic surveillance. Most cases of clozapine-induced neutropenia and agranulocytosis occur during the first three months of treatment. It's extremely rare after the first year of treatment. However, we present the case of a late-onset of sudden severe agranulocytosis following an influenza vaccine, after more than 156 months of stable neutrophil counts on clozapine. Clinicians must keep in mind that this complication can occur at any time during the treatment course and may wish to increase the frequency of hematologic surveillance following an influenza vaccine or even consider a risk-benefit approach. Considering the importance of the influenza vaccination and the seriousness of agranulocytosis, further studies are needed to elucidate a potential increase in the risk of severe neutropenia in patients on clozapine receiving the influenza vaccine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.