Evidence map›Paper›PMID 31327978›Full record

ArticleNature physics2019

Guiding self-organized pattern formation in cell polarity establishment.

Peter Gross, K Vijay Kumar, Nathan W Goehring, Justin S Bois, Carsten Hoege, Frank Jülicher, Stephan W Grill

Abstract read
In one paragraph

Article in Nature physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
  2. Article
  3. Actin network heterogeneity tunes activator-inhibitor dynamics at the cell cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  20. Three-dimensional chiral morphodynamics of chemomechanical active shells.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peter Gross *BIOTEC, TU Dresden, Tatzberg 47/49, 01307, Dresden, Germany.
K Vijay Kumar *International Centre for Theoretical Sciences, Tata Institute of Fundamental Research, Bengaluru 560089, India.
Nathan W GoehringThe Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Justin S BoisCalifornia Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125, USA.
Carsten HoegeMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Frank JülicherMax Planck Institute for the Physics of Complex Systems, Nöthnitzer Strasse 38, 01187 Dresden, Germany.
Stephan W GrillBIOTEC, TU Dresden, Tatzberg 47/49, 01307, Dresden, Germany.

Funding

Cancer Research UK 16797European Research Council 281903Medical Research Council FC001086Wellcome Trust FC001086
6 · The paper itself

Abstract

Spontaneous pattern formation in Turing systems relies on feedback. Patterns in cells and tissues however often do not form spontaneously, but are under control of upstream pathways that provide molecular guiding cues. The relationship between guiding cues and feedback in controlled biological pattern formation remains unclear. We explored this relationship during cell polarity establishment in the one-cell-stage

Identifiers

PMID31327978
PMCPMC6640039

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.