Evidence map›Paper›PMID 31327960›Full record

ArticleCurrent immunology reviews2019

Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond.

Barbara L Shacklett

Open access · greenAbstract read
In one paragraph

Article in Current immunology reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Review
  3. Innate Immune Protection Against HIV in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  4. Gastrointestinal MAIT cells in chronic HIV-1 infection.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Weight Gain After HIV Therapy Initiation: Pathophysiology and Implications.The Journal of clinical endocrinology and metabolism · 2024 · on this map
    Review
  9. Article
  10. Review
  11. Article
  12. Semen: A modulator of female genital tract inflammation and a vector for HIV-1 transmission.American journal of reproductive immunology (New York, N.Y. : 1989) · 2021
    Review
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Barbara L ShacklettDepartment of Medical Microbiology and Immunology.
University of California, Davis · US

Funding

HIV-Specific T Cell Responses in Rectal MucosaR01AI057020 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI SHACKLETT, BARBARA L. · 2003 to 2016
$6.2M
Intestinal MAIT Cells in HIV InfectionR01DK108350 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PAQUIN-PROULX, DOMINIC, SANDBERG, JOHAN K · 2015 to 2019
$2.5M
NIAID NIH HHS R01 AI057020NIDDK NIH HHS R01 DK108350
6 · The paper itself

Abstract

As our understanding of mucosal immunity increases, it is becoming clear that the host response to HIV-1 is more complex and nuanced than originally believed. The mucosal landscape is populated with a variety of specialized cell types whose functions include combating infectious agents while preserving commensal microbiota, maintaining barrier integrity, and ensuring immune homeostasis. Advances in multiparameter flow cytometry, gene expression analysis and bioinformatics have allowed more detailed characterization of these cell types and their roles in host defense than was previously possible. This review provides an overview of existing literature on immunity to HIV-1 and SIVmac in mucosal tissues of the female reproductive tract and the gastrointestinal tract, focusing on major effector cell populations and briefly summarizing new information on tissue resident memory T cells, T

Indexed as

adaptivegutHIV-1innatemucosaSIVT-cell

Identifiers

PMID31327960
PMCPMC6640863
OpenAlexW2805038712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.