ArticleTurkish journal of haematology : official journal of Turkish Society of Haematology2019
A Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience
Open access · diamondAbstract readMulticenter Study
In one paragraph
Article in Turkish journal of haematology : official journal of Turkish Society of Haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Bridging the gaps between randomized controlled trials and real-world use of thrombopoietin receptor agonists for adult primary immune thrombocytopenia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Eltrombopag Effectiveness and Tolerability in Chronic Immune Thrombocytopenia: A Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Original Versus Generic Eltrombopag in Patients with Immune Thrombocytopenia: A Prospective Multi-Center Experience on Efficacy and Safety.Journal of clinical medicine · 2026Article
- An Umbrella Review of Meta-Analyses on the Efficacy and Safety of Eltrombopag in Immune Thrombocytopenia.Health science reports · 2025Review
- Cancer treatment-induced thrombocytopenia: diagnosis, mechanisms and management.Frontiers in immunology · 2025Review
- Article
- Real-world experience of thrombopoietin receptor agonists in pediatric immune thrombocytopenia: a report from a Chinese tertiary children's hospital.Translational pediatrics · 2024Article
- Efficacy and safety of avatrombopag for thrombocytopenia following allogeneic hematopoietic stem cell transplantation: A real-world data evaluation on 14 cases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Could Antinuclear Antibody Positivity Be a Factor Affecting Treatment Response in Immune Thrombocytopenia Patients on Eltrombopag?Turkish journal of haematology : official journal of Turkish Society of Haematology · 2022Article
- Efficiency and safety of eltrombopag for multi-line failed Chinese patients with immune thrombocytopenia: cases with decreased megakaryocyte response well from single-center experience.Immunologic research · 2022Article
- Real-world experience of eltrombopag in immune thrombocytopenia.American journal of blood research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
84 authors at 20 institutions in 1 country.
Demet ÇekdemirAnadolu Medical Center, Bone Marrow Transplantation Center, Department of Hematology, Kocaeli, TurkeyORCID 0000-0002-1881-5166
Serkan GüvençYeni Yüzyıl University Gaziosmanpaşa Hospital, Department of Hematology, İstanbul, TurkeyORCID 0000-0002-4476-2651
Füsun Özdemirkıranİzmir Atatürk Training and Research Hospital, Clinic of Hematology, İzmir, TurkeyORCID 0000-0003-3942-2035
Ali EserMarmara University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0001-9423-928X
Tayfur ToptaşMarmara University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0002-2690-8581
Vildan ÖzkocamanUludağ University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Bursa, TurkeyORCID 0000-0003-0014-7398
Handan Haydaroğlu ŞahinGaziantep University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Gaziantep, TurkeyORCID 0000-0002-3467-8819
Esra Ermiş TurakErciyes University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Kayseri, TurkeyORCID 0000-0002-0058-4478
Ramazan EsenVan Yüzüncü Yıl University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Van, TurkeyORCID 0000-0001-8078-5458
Melda Cömertİnönü University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Malatya, TurkeyORCID 0000-0002-7798-4349
Sevil Sadriİstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0001-6009-3008
Müzeyyen AslanerBülent Ecevit University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Zonguldak, TurkeyORCID 0000-0001-6621-3138
Bahar Uncu UluDr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Clinic of Hematology, Ankara, TurkeyORCID 0000-0002-6230-9519
Abdullah KarakuşDicle University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Diyarbakır, TurkeyORCID 0000-0003-2090-4392
Derya Selim BapurKaradeniz Teknik University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Trabzon, TurkeyORCID 0000-0002-5345-3914
İnci AlacacıoğluDokuz Eylül University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İzmir, TurkeyORCID 0000-0002-8187-7159
Demet AydınOkmeydanı Training and Research Hospital, Clinic of Hematology, İstanbul, TurkeyORCID 0000-0001-9883-6372
Atakan TekinalpNamık Kemal University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Tekirdağ, TurkeyORCID 0000-0001-7937-4045
Sinem Namdaroğluİzmir Bozyaka Training and Research Hospital, Clinic of Hematology, İzmir, TurkeyORCID 0000-0002-8074-7301
Funda CeranAnkara Numune Training and Research Hospital, Clinic of Hematology, Ankara, TurkeyORCID 0000-0003-3173-7614
Pınar TarkunKocaeli University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Kocaeli, TurkeyORCID 0000-0003-0851-3583
Demet KiperEge University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İzmir, TurkeyORCID 0000-0003-2448-7346
Mustafa ÇetinerKoç University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0002-5903-8973
Mustafa Yenerelİstanbul University İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0002-6473-1342
Ahmet Muzaffer DemirTrakya University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Edirne, TurkeyORCID 0000-0002-2073-5405
Güven YılmazDr. Lütfi Kırdar Kartal Training and Research Hospital, Clinic of Hematology, İstanbul, TurkeyORCID 0000-0001-9972-2537
Hatice TerziCumhuriyet University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Sivas, TurkeyORCID 0000-0003-3471-1305
Erden AtillaAnkara University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, TurkeyORCID 0000-0002-8613-2105
Ümit Yavuz MalkanHacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, TurkeyORCID 0000-0001-5444-4895
Kadir AcarGazi University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, TurkeyORCID 0000-0001-9225-0215
Erman ÖztürkKoç University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0002-1559-8047
Anıl TombakMersin University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Mersin, TurkeyORCID 0000-0002-7195-1845
Cenk SunuSakarya University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Sakarya, TurkeyORCID 0000-0002-6513-6211
Ozan SalimAkdeniz University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Antalya, TurkeyORCID 0000-0001-6687-0189
Nevin AlayvazOndokuz Mayıs University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Samsun, TurkeyORCID 0000-0003-3292-8519
Özkan SayanMedicana Çamlıca Hospital, Clinic of Hematology, İstanbul, TurkeyORCID 0000-0003-1306-8082
Ülkü OzanMedical Park Hospital, Clinic of Hematology, Bursa, TurkeyORCID 0000-0002-1987-8062
Mesut AyerHaseki Training and Research Hospital, Clinic of Hematology, İstanbul, TurkeyORCID 0000-0003-1977-0104
Zafer GökgözMedicana International Ankara Hospital, Clinic of Hematology, Ankara, TurkeyORCID 0000-0002-7369-3376
Neslihan AndıçEskişehir Osmangazi University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Eskişehir, TurkeyORCID 0000-0003-0510-4733
Ebru KızılkılıçAcıbadem Kozyatağı Hospital, Clinic of Hematology, İstanbul, TurkeyORCID 0000-0002-2792-0179
Figen NoyanBaşkent University İstanbul Hospital, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0002-8761-4704
Mehmet ÖzenTokat Gaziosmanpaşa University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Tokat, TurkeyORCID 0000-0002-0910-9307
Funda Pepedil TanrıkuluDr. Ersin Arslan Training and Research Hospital, Clinic of Hematology, Gaziantep, TurkeyORCID 0000-0003-1878-1872
Güçhan AlanoğluSüleyman Demirel University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Isparta, TurkeyORCID 0000-0002-8089-9401
Hasan Atilla ÖzkanYeditepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0001-5590-972X
Vahap AslanÜmit Hospital, Clinic of Hematology, Eskişehir, TurkeyORCID 0000-0003-2510-4060
Güven ÇetinBezmialem Vakıf University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0003-2955-355X
Alev Akyol Erikçiİstanbul Yeni Yüzyıl University Gaziosmanpaşa Hospital Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0002-8969-6619
Burak DeveciMedstar Antalya Hospital, Clinic of Hematology, Antalya, TurkeyORCID 0000-0001-5820-1903
Fadime Ersoy DursunGöztepe Training and Research Hospital, Clinic of Hematology, İstanbul, TurkeyORCID 0000-0002-3577-188X
Hasan DermenciHaydarpaşa Numune Training and Research Hospital, Clinic of Hematology, İstanbul, TurkeyORCID 0000-0002-2244-5006
Pelin AytanBaşkent University Training and Research Hospital, Bone Marrow and Stem Cell Transplantation Center, Department of Hematology, Adana, TurkeyORCID 0000-0002-4213-1565
Mehmet GündüzAtatürk Training and Research Hospital, Clinic of Hematology, Ankara, TurkeyORCID 0000-0001-9105-6429
Volkan KarakuşMuğla Sıtkı Koçman University Training and Research Hospital, Department of Hematology, Muğla, TurkeyORCID 0000-0001-9178-2850
Can ÖzlüMinistry of Health Erzurum Regional Training and Research Hospital, Clinic of Hematology, Erzurum, TurkeyORCID 0000-0002-9573-1177
Sinan DemircioğluVan Yüzüncü Yıl University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Van, TurkeyORCID 0000-0003-1277-5105
Olga Meltem Akay YanarEskişehir Osmangazi University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Eskişehir, TurkeyORCID 0000-0002-6759-1939
Düzgün ÖzatlıOndokuz Mayıs University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Samsun, TurkeyORCID 0000-0001-6265-9378
Levent ÜndarAkdeniz University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Antalya, TurkeyORCID 0000-0002-9853-5075
Eyüp Naci TiftikMersin University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Mersin, TurkeyORCID 0000-0002-3178-6005
Ayhan Gülsan Türköz SucakGazi University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, TurkeyORCID 0000-0002-7707-0029
İbrahim HaznedaroğluHacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, TurkeyORCID 0000-0001-8028-9462
Muhit ÖzcanAnkara University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, TurkeyORCID 0000-0002-1326-1918
Mehmet ŞencanCumhuriyet University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Sivas, TurkeyORCID 0000-0002-1459-3906
Murat TombuloğluEge University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İzmir, TurkeyORCID 0000-0002-8340-7476
Gülsüm ÖzetAnkara Numune Training and Research Hospital, Clinic of Hematology, Ankara, TurkeyORCID 0000-0003-2658-5978
Oktay Bilgirİzmir Bozyaka Training and Research Hospital, Clinic of Hematology, İzmir, TurkeyORCID 0000-0001-9579-0583
Burhan TurgutNamık Kemal University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Tekirdağ, TurkeyORCID 0000-0001-5729-0043
Mehmet Ali ÖzcanDokuz Eylül University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İzmir, TurkeyORCID 0000-0001-7842-9702
Kadriye Bahriye PayzınYeni Yüzyıl University Gaziosmanpaşa Hospital, Department of Hematology, İstanbul, TurkeyORCID 0000-0002-2372-4314
Mehmet SönmezKaradeniz Teknik University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Trabzon, TurkeyORCID 0000-0002-2176-4371
Orhan AyyıldızDicle University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Diyarbakır, TurkeyORCID 0000-0001-5673-8408
Mehmet Sinan DalDr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Clinic of Hematology, Ankara, TurkeyORCID 0000-0002-5994-2735
Şehmus ErtopBülent Ecevit University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Zonguldak, TurkeyORCID 0000-0001-8771-7343
Mehmet TurgutOndokuz Mayıs University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Samsun, TurkeyORCID 0000-0002-1036-0232
Teoman Soysalİstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0002-7417-2118
Emin Kayaİnönü University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Malatya, TurkeyORCID 0000-0001-8605-8497
Ali ÜnalErciyes University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Kayseri, TurkeyORCID 0000-0003-4525-3426
Mustafa PehlivanGaziantep University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Gaziantep, TurkeyORCID 0000-0002-6692-085X
Işık AtagündüzMarmara University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0002-7876-6896
Tülin Tuğlular FıratlıMarmara University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, TurkeyORCID 0000-0003-3232-7545
Güray SaydamEge University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İzmir, TurkeyORCID 0000-0001-8646-1673
Reyhan Diz Küçükkayaİstanbul University Science Faculty, Department of Molecular Biology and Genetics, İstanbul, TurkeyORCID 0000-0001-5814-7118
Marmara University · TREge University · TRIstanbul Yeni Yüzyıl University · TROndokuz Mayıs University · TRAkdeniz University · TRAnkara Numune Eğitim ve Araştırma Hastanesi · TRAnkara Onkoloji Eğitim ve Araştırma Hastanesi · TRAnkara University · TRBaşkent University · TRBülent Ecevit University · TRDicle University · TRDokuz Eylül University · TRErciyes University · TREskişehir Osmangazi University · TRGaziantep University · TRGazi University · TRHacettepe University · TRInonu University · TRIstanbul University · TRIstanbul University-Cerrahpaşa · TR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP). Materials and Methods: A total of 285 chronic ITP patients (187 women, 65.6%; 98 men, 34.4%) followed in 55 centers were enrolled in this retrospective cohort. Response to treatment was assessed according to platelet count (/mm Results: The median age at diagnosis was 43.9±20.6 (range: 3-95) years and the duration of follow-up was 18.0±6.4 (range: 6-28.2) months. Overall response rate was 86.7% (n=247). Complete and partial responses were observed in 182 (63.8%) and 65 (22.8%) patients, respectively. Thirty-eight patients (13.4%) did not respond to eltrombopag treatment. For patients above 60 years old (n=68), overall response rate was 89.7% (n=61), and for those above 80 years old (n=12), overall response rate was 83% (n=10). Considering thrombocyte count before treatment, eltrombopag significantly increased platelet count at the 1 Conclusion: Results of the current study imply that eltrombopag is an effective therapeutic option even in elderly patients with chronic ITP. However, patients must be closely monitored for response and side effects during treatment. Since both response and side effects may be variable throughout the follow-up period, patients should be evaluated dynamically, especially in terms of thrombotic risk factors.
Indexed as
AdolescentAdultAgedAged, 80 and overBenzoatesChildChild, PreschoolChronic DiseaseFemaleHumansHydrazinesMaleMiddle AgedPurpura, Thrombocytopenic, IdiopathicPyrazolesYoung AdultBenzoateseltrombopagHydrazinesPyrazolesEltrombopagImmune thrombocytopenicThrombocytopenia
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